F12
F12, F.XII, F 12, F.12 or F-12 may refer to :
Factor XII
Coagulation factor XII, also known as Hageman factor, is a plasma protein. It is the zymogen form of factor XIIa, an enzyme (EC 3.4.21.38) of the serine protease (or serine endopeptidase) class. In humans, factor XII is encoded by the F12 gene.
Structure
Human Factor XII is 596 amino acids long and consists of two domains, the heavy chain (353 residues) and light chain (243 residues) held together by a disulfide bond. It is 80,000 daltons. Its heavy chain contains two fibronectin-type domains (type I and II), two epidermal growth factor-like domains, a kringle domain, and a proline-rich region, and its light chain contains the protease domain. Recently, the structure of the FnI-EGF-like tandem domain of coagulation factor XII was solved by x-ray crystallography.
Function
Factor XII is part of the coagulation cascade and activates factor XI and prekallikrein in vitro. Factor XII itself is activated to factor XIIa by negatively charged surfaces, such as glass. This is the starting point of the intrinsic pathway. Factor XII can also be used to start coagulation cascades in laboratory studies.
Podcasts:
-
by They Might Be Giants
-
by Die Aerzte
-
by AFI
-
by Azra
-
by Ataris
-
by Cranberries
-
by Danny!
-
by Dolores O'Riordan
-
by Masters of Reality
-
by OV7
-
by Onda Vaselina
-
by Gyroscope
-
by View
-
by Datarock
-
by V
-
by Sin Fang Bous
-
by Wwf
-
by Guardians
4 Of 2
by: They Might Be GiantsUnderneath a big clock
At the corner of 5th Avenue and 22nd Street
I stood and waited for a girl I knew
At the spot where we agreed to meet
It was four minutes of two
At four of two, I stood waiting for the girl
I was four minutes early for the date we had planned
I was planning to say I was in love with her
Just as soon as she showed for a two o'clock date
And the clock said four of two
At four of two, I was staring into space
She was not yet late, according to the clock
I was feeling nervous so I kept looking up
At the clock sticking out of the side of the building
And it still said four of two
At four of two, I began to feel tired
And I rubbed my eyes, and again I checked the time
It seemed as if the sky was growing dark
But I felt reassured when I looked at the clock
And it still said four of two
I lay my head down on the sidewalk
So in case she were coming I would have a better view
But no one was there so I stretched out
And closed my eyes for a second or two
It was four minutes of two
At once I awoke to a futuristic world
There were flying cars and gigantic metal bugs
I'd grown a beard, it was long and white
But I knew that the girl would be coming very soon
For though everything had changed, there was still that clock
Latest News for: f12
- 1