F-15,599

F-15,599, also known as NLX-101, is a very potent and highly selective 5-HT_1A receptor full agonist. It displays functional selectivity (also known as "biased agonism") by strongly activating 5-HT_1A receptors in the postsynaptic prefrontal cortex while having little effect on somatodendritic autoreceptors in the raphe nucleus. As a result, it has been touted as a preferential postsynaptic 5-HT_1A receptor agonist and has been investigated as a novel potential antidepressant.

In cognitive tests in rodent, F-15,599 attenuates memory deficits elicited by the NMDA receptor antagonist PCP, suggesting that it may improve cognitive function in disorders such as schizophrenia.

A subsequent study showed that F-15,599 reduces breathing irregularity and apneas observed in mice with mutations of the MeCP2 gene. Dysruption of MeCP2 gene expression underlies Rett syndrome, a debilitating neurodevelopmental orphan disease.

F-15,599 was discovered and initially developed by Pierre Fabre Médicament, a French pharmaceuticals company. In September 2013, F-15,599 was out-licensed to Neurolixis, a California-based biotechnology company. Neurolixis announced that it intends to re-purpose F-15,599 for the treatment of Rett syndrome. and obtained Orphan Drug designation from the United States Food and Drug Administration (FDA) and from the European Commission for this indication.

United States military aircraft designation systems

The United States Military Aircraft Designation System was first designed in 1919 when the US Army's Aeronautical Division became the United States Army Air Service. Before this aircraft were put into service under their manufacturers' designations.

History

United States Army Air Service 1919 to 1924

During this period Type Designations used by the United States Army Air Service were allotted, using two or three letters, which were an abbreviation of the aircraft's purpose. Examples include GA for Ground Attack aircraft; NO for Night Observation aircraft and NBS for Night Bombardment, Short Distance aircraft.

Army aviation 1924 to 1962

From 1924 to 1947 the Air Service, United States Army Air Corps, United States Army Air Forces and United States Air Force used a designation system based on mission category, with each model in a category numbered sequentially. In 1947, the designation system was extensively overhauled, with several categories being dispensed with, and others renamed For instance, the Lockheed P-80 Shooting Star (Pursuit) was redesignated as F-80 (Fighter), while the A-26 medium bomber/attack aircraft was redesignated as the B-26, reusing the designation, the Martin B-26 having retired in the meantime.

F15

F15 or F-15 may refer to:

Aircraft

Video games

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