United States military aircraft designation systems

The United States Military Aircraft Designation System was first designed in 1919 when the US Army's Aeronautical Division became the United States Army Air Service. Before this aircraft were put into service under their manufacturers' designations.

History

United States Army Air Service 1919 to 1924

During this period Type Designations used by the United States Army Air Service were allotted, using two or three letters, which were an abbreviation of the aircraft's purpose. Examples include GA for Ground Attack aircraft; NO for Night Observation aircraft and NBS for Night Bombardment, Short Distance aircraft.

Army aviation 1924 to 1962

From 1924 to 1947 the Air Service, United States Army Air Corps, United States Army Air Forces and United States Air Force used a designation system based on mission category, with each model in a category numbered sequentially. In 1947, the designation system was extensively overhauled, with several categories being dispensed with, and others renamed For instance, the Lockheed P-80 Shooting Star (Pursuit) was redesignated as F-80 (Fighter), while the A-26 medium bomber/attack aircraft was redesignated as the B-26, reusing the designation, the Martin B-26 having retired in the meantime.

F15

F15 or F-15 may refer to:

Aircraft

Video games

Other

F-15063

F-15,063 is an orally active potential antipsychotic, and an antagonist at the D₂/D₃ receptors, partial agonist at the D₄ receptor, and agonist at the 5-HT_1A receptors. It has greater efficacy at the 5-HT_1A receptors than other antipsychotics, such as clozapine, aripiprazole, and ziprasidone. This greater efficacy may lead to enhanced antipsychotic properties, as antipsychotics that lack 5-HT_1A affinity are associated with increased risk of extrapyramidal symptoms, and lack of activity against the negative symptoms of schizophrenia.

As expression of immediate-early gene (IEG) in certain brain regions may represent markers of anti-psychotic activity, expression of immediate-early gene mRNA in the prefrontal cortex and striatum was measured. Treatment with F-15,063 resulted in induction of c-fos and fosB mRNA expression in the prefrontal cortex. In the striatum, F-15,063 treatment resulted in induction of all IEGs studied (c-fos, fosB, zif268, c-jun, junB, nor1, nur77, arc).

F-15,063 was tested in several animal models that predict antipsychotic activity to help determine the behavioral profile. Administration of F-15,063 blocked amphetamine and ketamine induced hyperlocomotion, but did not affect baseline, spontaneous locomotor activity. In addition, F-15,063 did not produce catalepsy, a side effect of other antipsychotics, such as haloperidol. This inhibition of catalepsy is 5-HT_1A receptor mediated, as pretreatment with the 5-HT_1A antagonist WAY-100635 reinstated catalepsy. The level of catalepsy did not increase with chronic dosing, and there was no evidence for serotonin syndrome at clinically relevant doses.