Paired box protein Pax-6 also known as aniridia type II protein (AN2) or oculorhombin is a protein that in humans is encoded by the PAX6 gene. Pax6 is a transcription factor present during embryonic development. The encoded protein contains two different binding sites that are known to bind DNA and function as regulators of gene transcription. It is a key regulatory gene of eye and brain development. Within the brain, the protein is involved in development of the specialized cells that process smell. As a transcription factor, Pax6 activates and/or deactivates gene expression patterns to ensure for proper development of the tissue. Mutations of the Pax6 gene are known to cause various disorders of the eyes. Two common disorders associated with a mutation are: aniridia, the absence of the iris, and Peter’s anomaly, thinning and clouding of the cornea. Scientists have created a “tae” model using mice during which time the mouse does not express Pax6. The "knockout” model is eyeless or has very underdeveloped eyes further indicating Pax6 is required for proper eye development.
Slipknot is the self titled debut studio album by American heavy metal band Slipknot. It was released on 29 June 1999 through Roadrunner Records, following a demo containing a few of the songs which had been released in 1998, and was reissued in December 1999 with a slightly altered track listing and mastering as the result of a lawsuit. It was the first release by the band to be produced by Ross Robinson, who sought to refine Slipknot's sound rather than alter the group's musical direction.
The album spans several genres, but is generally noted for its extensive percussion and overall heavy sound. It was well received by fans and critics alike and was responsible for bringing Slipknot a large increase in popularity. The album peaked at number 51 on the Billboard 200, and has gone on to become certified double platinum in the United States, making it the band's best selling album. It was voted the best debut album of the last 25 years by readers of Metal Hammer magazine.
IZO is a 2004 Japanese film, directed by Takashi Miike. The main character of the film is Izo Okada (1832–1865), the historical samurai and assassin in 19th century Japan who was tortured and executed by beheading in Tosa.
Izo appeared previously in Hideo Gosha's Hitokiri (1969), then played by Shintaro Katsu. However, Miike's portrayal of the character (or rather his spirit) transcends reality (and time and space) and is more of a surrealist exposé of Izo's exceedingly bloody yet philosophical encounters in an afterlife heavy on symbolism, occasionally interrupted by stock footage of World War II accompanied by acid-folk singer Kazuki Tomokawa on guitar. Kazuya Nakayama plays Izo, and the countless characters he encounters on his journey include for instance Takeshi Kitano and Bob Sapp.
Izumo Airport (出雲空港, Izumo Kūkō) (IATA: IZO, ICAO: RJOC) is an airport in the Hikawa area of Izumo, Shimane Prefecture, Japan, about 20–30 minutes by car from central Izumo or Matsue city centre. This airport is also known as Izumo En-Musubi Airport「出雲縁結び空港」; meaning Izumo Airport of Romantic Fate.
Windy Whistle by Alice Lewis
Fall asleep now,
I will count until you make a wish,
Softly whisper quiet magic numbers,
Conjure up the little sound that’s carried in the wind,
When freed it wakes the trees out of their slumber.
CHORUS: Windy whistles, shinning drizzle,
Blow the sound away,
Drum the branches,
Lead the dances now.
You will soon find out the way to be invisible,
Hide behind the smallest leaf,
If you wait for long enough you’ll see it happening,
Those lonely sylphs come out of the green.
CHORUS: Windy whistles, shinning drizzle,
Blow the sound away,
Drum the branches,
Lead the dances now.
Windy whistles sew the hearts on,
Find the secret way,
See the traces, hiding places now.
But don’t try to tame them,
Oh, you’ll end the game then,
So just come to tell.
CHORUS: Windy whistles, shinning drizzle,
Blow the sound away,
Drum the branches,
Lead the dances now.
Windy whistles sew the hearts on,
Find the secret way,
See the traces, hiding places now.
CHORUS: Windy whistles, shinning drizzle,
Blow the sound away,
Drum the branches,