Exile
Exile means to be away from one's home (i.e. city, state or country), while either being explicitly refused permission to return and/or being threatened with imprisonment or death upon return. It can be a form of punishment and solitude. It is common to distinguish between internal exile, i.e., forced resettlement within the country of residence, and external exile, deportation outside the country of residence. Although most commonly used to describe an individual situation, the term is also used for groups (especially ethnic or national groups), or for an entire government. Terms such as diaspora and refugee describe group exile, both voluntary and forced, and government in exile describes a government of a country that has been forced to relocate and argue its legitimacy from outside that country. Exile can also be a self-imposed departure from one's homeland. Self-exile is often depicted as a form of protest by the person that claims it, to avoid persecution or legal matters (such as tax or criminal allegations), an act of shame or repentance, or isolating oneself to be able to devote time to a particular pursuit. Article 9 of the Universal Declaration of Human Rights states that "No one shall be subjected to arbitrary arrest, detention or exile."
Last Exile
Last Exile (ラストエグザイル, Rasuto Eguzairu) is a Japanese animated television series created by Gonzo. It featured a production team led by director Koichi Chigira, character designer Range Murata, and production designer Mahiro Maeda. The three had previously worked together in Blue Submarine No. 6, one of the first CG anime series. Last Exile aired on TV Tokyo between April 7, 2003 and September 29, 2003. A sequel series, Last Exile -Fam, The Silver Wing- (ラストエグザイル～銀翼のファム～, Rasuto Eguzairu Gin'yoku no Famu), aired between October 15, 2011 and March 23, 2012. A film adaptation of the series, Last Exile -Fam, The Silver Wing-: Over the Wishes, will be released on February 6, 2016.
The story is set on the fictional world of Prester, where its inhabitants use aerial vehicles known as vanships as a means of transportation. On this world which is divided in eternal conflict between the nations of Anatoray and Disith, sky couriers Claus Valca and Lavie Head must deliver a girl who holds the key to uniting the two factions. Although Prester itself is not a representation of Earth, it features technology reminiscent of nineteenth-century Europe at the dawn of the Industrial Revolution. Many of its designs were also inspired by Germany's technological advances during the interwar period.
Exile (producer)
Aleksander Manfredi, better known by his stage name Exile, is an American hip hop DJ, producer and occasional rapper.
Career
His first record appearances were as a member of the hip hop duo Emanon with the rapper Aloe Blacc. They released various mixtapes, beginning in 1995 with "Stretch Marx" before releasing their first album, Anon & On. After 2002, Exile went on to release one more Emanon album, The Waiting Room (2005), a solo album, Dirty Science (2006), and another collaborative effort with the rapper Blu, Below the Heavens (2007). Exile released two more solo albums, Radio in 2009 and 4TRK Mind in 2011. 2013 saw the release of his instrumental album, Zip Disks & Floppies.
Style and influences
Exile is known for "coarsely chopped beats" that give off "laid back soulful vibes". He claims his influences to be the contemporary producers J Dilla, Jon Brion and Madlib.
Discography
Studio albums
Nuclear receptor coactivator 2
The nuclear receptor coactivator 2 also known as NCoA-2 is a protein that in humans is encoded by the NCOA2 gene. NCoA-2 is also frequently called glucocorticoid receptor-interacting protein 1 (GRIP1), steroid receptor coactivator-2 (SRC-2), or transcriptional mediators/intermediary factor 2 (TIF2).
Function
NCoA-2 is a transcriptional coregulatory protein that contains several nuclear receptor interacting domains and an intrinsic histone acetyltransferase activity. NCOA2 is recruited to DNA promotion sites by ligand-activated nuclear receptors. NCOA2 in turn acetylates histones, which makes downstream DNA more accessible to transcription. Hence, NCOA2 assists nuclear receptors in the upregulation of DNA expression.
GRIP1 is a transcriptional co-activator of the glucocorticoid receptor and interferon regulatory factor 1 (IRF1).
Interactions
Nuclear receptor coactivator 2 has been shown to interact with:
Nuclear receptor coactivator 3
The nuclear receptor coactivator 3 also known as NCOA3 is a protein that, in humans, is encoded by the NCOA3 gene. NCOA3 is also frequently called 'amplified in breast 1' (AIB1), steroid receptor coactivator-3 (SRC-3), or thyroid hormone receptor activator molecule 1 (TRAM-1).
Function
NCOA3 is a transcriptional coactivator protein that contains several nuclear receptor interacting domains and an intrinsic histone acetyltransferase activity. NCOA3 is recruited to DNA promotion sites by ligand-activated nuclear receptors. NCOA3, in turn, acylates histones, which makes downstream DNA more accessible to transcription. Hence, NCOA3 assists nuclear receptors in the upregulation of gene expression.
Clinical significance
The ratio of PAX2 to AIB-1 protein expression may be predictive of the effectiveness of tamoxifen in breast cancer treatment.
Interactions
Nuclear receptor coactivator 3 has been shown to interact with:
Nuclear receptor coactivator 1
The nuclear receptor coactivator 1 (NCOA1) is a transcriptional coregulatory protein that contains several nuclear receptor interacting domains and an intrinsic histone acetyltransferase activity (EC 2.3.1.48). NCOA1 is recruited to DNA promotion sites by ligand-activated nuclear receptors. NCOA1, in turn, acylates histones, which makes downsteam DNA more accessible to transcription. Hence, NCOA1 assists nuclear receptors in the upregulation of DNA expression.
NCOA1 is also frequently called steroid receptor coactivator-1 (SRC-1).
Interactions
Nuclear receptor coactivator 1 possesses a basic helix-loop-helix (bHLH) domain and has been shown to interact with:
References
External links
Podcasts:
