FAP
FAP may refer to:
Fibroblast activation protein, alpha
Fibroblast activation protein alpha is a 170 kDa melanoma membrane-bound gelatinase, protein that in humans is encoded by the FAP gene.
Function
The protein encoded by this gene is a homodimeric integral membrane gelatinase belonging to the serine protease family. It is selectively expressed in reactive stromal fibroblasts of epithelial cancers, granulation tissue of healing wounds, and malignant cells of bone and soft tissue sarcomas. This protein is thought to be involved in the control of fibroblast growth or epithelial-mesenchymal interactions during development, tissue repair, and epithelial carcinogenesis.
FAP, also known as seprase, belongs to the clan SC proteases and is a member of the S9B prolyl oligopeptidase subfamily. Other members of the S9B subfamily are DPPIV, DPP8 and DPP9. FAP is most closely related to DPPIV and they share about 50% of their amino acids.
FAP is catalytically active as a 170kD dimer and has dipeptidase and gelatinase activity. Its gelatinase activity requires a glycine in P2 position.
FAP 1117
FAP 1117 was the predecessor of the latest FAP military truck version, FAP 1118. This is an all-terrain vehicle developed by VTI and scheduled for production by FAP factory in Priboj. It was not introduced in serial production, being only prototype, while it's lightly improved successor, FAP 1118 is in full serial production.
It is designed for transport of personnel, weapons and material of up to 4t gross weight, as well as for towing of artillery pieces and trailers. Equipped with all-wheel drive, locking of all differentials and powerful diesel engine, the vehicle is able to negotiate cross-country gradients of 60%. Central regulation of tire pressure assures high mobility over soft soil and its well thought out body geometry enables easy negotiating of natural and man-made obstacles such as trenches, railway embankments, escarps etc.
