Nuclear receptor coactivator 2

The nuclear receptor coactivator 2 also known as NCoA-2 is a protein that in humans is encoded by the NCOA2 gene. NCoA-2 is also frequently called glucocorticoid receptor-interacting protein 1 (GRIP1), steroid receptor coactivator-2 (SRC-2), or transcriptional mediators/intermediary factor 2 (TIF2).

Function

NCoA-2 is a transcriptional coregulatory protein that contains several nuclear receptor interacting domains and an intrinsic histone acetyltransferase activity. NCOA2 is recruited to DNA promotion sites by ligand-activated nuclear receptors. NCOA2 in turn acetylates histones, which makes downstream DNA more accessible to transcription. Hence, NCOA2 assists nuclear receptors in the upregulation of DNA expression.

GRIP1 is a transcriptional co-activator of the glucocorticoid receptor and interferon regulatory factor 1 (IRF1).

Interactions

Nuclear receptor coactivator 2 has been shown to interact with:

Nuclear receptor coactivator 3

The nuclear receptor coactivator 3 also known as NCOA3 is a protein that, in humans, is encoded by the NCOA3 gene. NCOA3 is also frequently called 'amplified in breast 1' (AIB1), steroid receptor coactivator-3 (SRC-3), or thyroid hormone receptor activator molecule 1 (TRAM-1).

Function

NCOA3 is a transcriptional coactivator protein that contains several nuclear receptor interacting domains and an intrinsic histone acetyltransferase activity. NCOA3 is recruited to DNA promotion sites by ligand-activated nuclear receptors. NCOA3, in turn, acylates histones, which makes downstream DNA more accessible to transcription. Hence, NCOA3 assists nuclear receptors in the upregulation of gene expression.

Clinical significance

The ratio of PAX2 to AIB-1 protein expression may be predictive of the effectiveness of tamoxifen in breast cancer treatment.

Interactions

Nuclear receptor coactivator 3 has been shown to interact with:

N&W 475

Strasburg Rail Road #475 is a former Norfolk & Western Railway M class 4-8-0 steam locomotive. It was built by the Baldwin Locomotive Works in 1906 as part of the N&W's first order of class M numbered 450–499. It is the only known 4-8-0 operating in North America and it appeared in Thomas and the Magic Railroad.

Cab Arrangement

Like the W class 2-8-0 Consolidation, there was no cab deck behind the backhead, the fireman shoveled coal from the tender deck and, along with the engineer, sat beside the firebox because the firebox came right to the back of the cab. The throttle lever hung down over the shoulder of the firebox, the reverser lever was in front of the engineer against the side of the firebox, with the water glass just above. The injector controls (A water valve, the overflow valve, and the operating lever.) were in front of him against the outer wall of the cab. Although slightly cramped, visibility to the front was superb. On the fireman's side, there was a water glass, injector controls, and a drop seat arranged like the engineer's.

Evil

Evil, in a general context, is the absence or opposite of that which is ascribed as being good. Often, evil is used to denote profound immorality. In certain religious contexts, evil has been described as a supernatural force. Definitions of evil vary, as does the analysis of its motives. However, elements that are commonly associated with evil involve unbalanced behavior involving expediency, selfishness, ignorance, or neglect.

In cultures with an Abrahamic religious influence, evil is usually perceived as the dualistic antagonistic opposite of good, in which good should prevail and evil should be defeated. In cultures with Buddhist spiritual influence, both good and evil are perceived as part of an antagonistic duality that itself must be overcome through achieving Śūnyatā meaning emptiness in the sense of recognition of good and evil being two opposing principles but not a reality, emptying the duality of them, and achieving a oneness.

The philosophical question of whether morality is absolute, relative, or illusory leads to questions about the nature of evil, with views falling into one of four opposed camps: moral absolutism, amoralism, moral relativism, and moral universalism.

Evil (Grinderman song)

"Evil" (often stylised as EVIL) is a song by alternative rock band Grinderman, written collectively by Nick Cave, Warren Ellis, Martyn P. Casey and Jim Sclavunos. The song was featured as the fifth track on the band's second and final studio album, Grinderman 2 (2010). On Record Store Day 2011, "Evil" was released as a limited edition single, on 12" vinyl with an enclosed CD, with various remixes.

Track listing

References

Evil (Howlin' Wolf song)

"Evil", sometimes listed as "Evil (Is Going On)", is a Chicago blues standard written by Willie Dixon.Howlin' Wolf recorded the song for Chess Records in 1954. It was included on the 1959 compilation album Moanin' in the Moonlight. When he re-recorded it for The Howlin' Wolf Album in 1969, "Evil" became Wolf's last charting single (#43 Billboard R&B chart).

The 1954 song features sidemen Hubert Sumlin and Jody Williams (guitars), Otis Spann (piano), Willie Dixon (double-bass), and Earl Phillips (drums). Wolf achieves a coarse, emotional performance with his strained singing, lapsing into falsetto. The song, a twelve-bar blues, is punctuated with a syncopated backbeat, brief instrumental improvisations, upper-end piano figures, and intermittent blues harp provided by Wolf. The lyrics caution about the "evil" that takes place in a man's home when he is away, concluding with "you better watch your happy home".

The song has been recorded by numerous artists, including: Luther Allison, Canned Heat, Captain Beefheart, Derek and the Dominos, Gary Moore, Cactus, The Faces, Dee Snider (with Widowmaker), Jake E. Lee, Monster Magnet, and Steve Miller. Koko Taylor's version of the song appeared in the 1987 film Adventures in Babysitting. Tom Jones recorded a version of the song in 2011, produced by Jack White. It includes a snippet of The Doors' "Wild Child". Jace Everett and C. C. Adcock also recorded a version, which was used as the featured song for the third season finale of the HBO series True Blood.