Estramustine

Estramustine (Emcyt, Estracit) is an antimicrotubule chemotherapy agent used to treat prostate cancer. It is a derivative of oestrogen (specifically, estradiol) with a nitrogen mustard-carbamate ester moiety. It has been withdrawn from a number of markets (Australia, Brazil, Ireland and Norway).

Clinical uses

Estramustine is indicated, in the US, for the palliative treatment of metastatic and/or progressive prostate cancer. Whereas in the UK it is indicated for the treatment of unresponsive or relapsing prostate cancer.

Adverse effects

Adverse effects by frequency:
Very common (>10% frequency):

Common (1-10% frequency):

Rare (<0.1% frequency):