E-selectin
E-selectin, also known as CD62 antigen-like family member E (CD62E), endothelial-leukocyte adhesion molecule 1 (ELAM-1), or leukocyte-endothelial cell adhesion molecule 2 (LECAM2), is a cell adhesion molecule expressed only on endothelial cells activated by cytokines. Like other selectins, it plays an important part in inflammation. In humans, E-selectin is encoded by the SELE gene.
Structure
E selectin has a cassette structure: an N-terminal, C-type lectin domain, an EGF (epidermal-growth-factor)-like domain, 6 Sushi domain (SCR repeat) units, a transmembrane domain (TM) and an intracellular cytoplasmic tail (cyto). The three-dimensional structure of the ligand-binding region of human E-selectin has been determined at 2.0 Å resolution in 1994. The structure reveals limited contact between the two domains and a coordination of Ca2+ not predicted from other C-type lectins. Structure/function analysis indicates a defined region and specific amino-acid side chains that may be involved in ligand binding. The E-selectin bound to sialyl-LewisX (SLeX; NeuNAcα2,3Galβ1,4[Fucα1,3]GlcNAc) tetrasaccharide was solved in 2000.
Annunciation
The Annunciation (from the Vulgate Latin annuntiatio (or nuntiatio) nativitatis Christi), also referred to as the Annunciation to the Blessed Virgin Mary, the Annunciation of Our Lady or the Annunciation of the Lord, is the Christian celebration of the announcement by the angel Gabriel to the Virgin Mary that she would conceive and become the mother of Jesus, the Son of God, marking his Incarnation. Gabriel told Mary to name her son Yehoshua , meaning "YHWH is salvation".
According to Luke 1:26, the Annunciation occurred "in the sixth month" of Elizabeth's pregnancy with John the Baptist. Many Christians observe this event with the Feast of the Annunciation on 25 March, an approximation of the northern vernal equinox nine full months before Christmas, the ceremonial birthday of Jesus. In England, this came to be known as Lady Day. It marked the new year until 1752. The 2nd-century writer Irenaeus of Lyon regarded the conception of Jesus as 25 March coinciding with the Passion.
Annunciation (disambiguation)
An "annunciation" is an announcement. The Annunciation, strictly the "Annunciation to Mary", is the revelation to Mary by the archangel Gabriel that she would conceive a child to be born the Son of God.
The term is also sometimes used as a formal term, especially in art history, of other similar biblical revelations to figures including Saint Joseph and the shepherds, or may refer to:
Art
Annunciation (Caravaggio)
The Annunciation is an oil painting by the Italian master Michelangelo Merisi da Caravaggio, finished around 1608. It housed in the Musée des Beaux-Arts de Nancy.
The painting has been considerably damaged and retouched, and what remains of Caravaggio's brushwork is the angel, who bears a resemblance to the figure in John the Baptist at the Fountain. The illusionistic treatment of the angel, floating on his cloud and seeming to protrude outside the picture plane, is more Baroque than is normal for Caravaggio, but the contrast between the energetic pose of the heavenly messenger and the receptive Mary is dramatically and psychologically effective. The loose brushwork is typical of Caravaggio's later period.
The painting was given by Henry II, Duke of Lorraine, to his primatial church in Nancy as the main altarpiece, and was perhaps acquired by one of the Duke's sons in the course of a visit to Malta in 1608.
Description
The painting is composed of two figures. The angel above the Virgin is attributed to being Gabriel who was the angel of the annunciation. The lilies that Gabriel holds are also a symbol of the Virgin. The Virgin is in a prostrate position as she is being told by Gabriel of God’s plan for her. The painting exhibits Caravaggio’s signature sfumato and tenebrism, with almost the entire painting being dark except for the two main figures.
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