Ephenidine
Ephenidine (also known as NEDPA and EPE) is a dissociative anesthetic that has been sold online as a designer drug. It is illegal in some countries as a structural isomer of the banned opioid drug lefetamine, but has been sold in countries where it is not yet banned.
Ephenidine and related diarylethylamines have been studied in vitro as treatments for neurotoxic injuries, and are antagonists of the NMDA receptor.
Metabolism
Ephenidine undergoes the following metabolic steps: N-oxidation, N-dealkylation, mono- and bis-hydroxylation of the benzene ring, and hydroxylation of the phenyl ring only after N-dealkylation. The dihydroxy metabolites were conjugated by methylation of one hydroxy group, and hydroxy metabolites by glucuronidation or sulfation.
Chemistry
Ephenidine reacts with reagent tests to give a semi-unique array of colors which can be used to aid its identification.
Legality
Sweden's public health agency suggested that Ephenidine be classified as a hazardous substance on the 1st of June, 2015. Due to that suggestion, Ephenidine became a scheduled substance, in Sweden, as of the 18th of August, 2015.
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