Enox Biopharma

Enox Biopharma is a Canadian company developing antimicrobial medical devices coated with Nitric Oxide.

These products include urinary catheters, endotracheal tubes, central venous lines and other short term indwelling devices. Nitric Oxide gas (gNO) is produced in various cell types, has a short half-life of about six seconds and is part of the body’s innate response to inflammatory and immune processes. More specifically, gNO has been shown to play an important role in vasodilatation, neurotransmission, angiogenesis, modulation of wound healing and response to infection. Experimental evidence has demonstrated a broad range of antimicrobial activity against a growing list of both gram-positive and gram-negative bacteria, fungi and viruses.

ENOX2

Ecto-NOX disulfide-thiol exchanger 2 is a protein that in humans is encoded by the ENOX2 gene.

The protein encoded by this gene is a growth-related cell surface protein. It was identified because it reacts with the monoclonal antibody KI in cells, such as the ovarian carcinoma line OVCAR-3, also expressing the CAKI surface glycoprotein. The encoded protein has two enzymatic activities: catalysis of hydroquinone or NADH oxidation, and protein disulfide interchange. The two activities alternate with a period length of about 24 minutes. The encoded protein also displays prion-like properties. Two transcript variants encoding different isoforms have been found for this gene.

References

Further reading

Human Genome Organisation

The Human Genome Organisation (HUGO) is an organization involved in the Human Genome Project, a project about mapping the human genome. HUGO was established in 1989 as an international organization, primarily to foster collaboration between genome scientists around the world. The HUGO Gene Nomenclature Committee (HGNC), sometimes referred to as "HUGO", is one of HUGO's most active committees and aims to assign a unique gene name and symbol to each human gene.

History

HUGO was established in late April 1988 at the first meeting dedicated to genome mapping at Cold Spring Harbor. The idea of starting the organization stemmed from a South African biologist by the name of Sydney Brenner, who is known for his significant contributions to work on the genetic code and other areas of molecular biology, as well as winning the Nobel prize in Physiology of Medicine in 2002. A Founding Council was elected at the meeting that total 42 scientists from 17 different countries. HUGO is grounded in Geneva Switzerland, and later went on to elect an additional 178 members, bringing the total up to 220.