LYN

Tyrosine-protein kinase Lyn is a protein that in humans is encoded in humans by the LYN gene.

Lyn is a member of the Src family of protein tyrosine kinases, which is mainly expressed in hematopoietic cells, in neural tissues liver, and adipose tissue. In various hematopoietic cells, Lyn has emerged as a key enzyme involved in the regulation of cell activation. In these cells, a small amount of LYN is associated with cell surface receptor proteins, including the B cell antigen receptor (BCR),CD40, or CD19. The abbreviation Lyn is derived from Lck/Yes novel tyrosine kinase, Lck and Yes also being members of the Src kinase family.

Function

Lyn has been described to have an inhibitory role in myeloid lineage proliferation. Following engagement of the B cell receptors, Lyn undergoes rapid phosphorylation and activation. LYN activation triggers a cascade of signaling events mediated by Lyn phosphorylation of tyrosine residues within the immunoreceptor tyrosine-based activation motifs (ITAM) of the receptor proteins, and subsequent recruitment and activation of other kinases including Syk, phosholipase Cγ2 (PLCγ2) and phosphatidyl inositol-3 kinase. These kinases provide activation signals, which play critical roles in proliferation, Ca²⁺ mobilization and cell differentiation. Lyn plays an essential role in the transmission of inhibitory signals through phosphorylation of tyrosine residues within the immunoreceptor tyrosine-based inhibitory motifs (ITIM) in regulatory proteins such as CD22, PIR-B and FCγRIIb1. Their ITIM phosphorylation subsequently leads to recruitment and activation of phosphatases such as SHIP-1 and SHP-1, which further downmodulate signaling pathways, attenuate cell activation and can mediate tolerance. In B cells, Lyn sets the threshold of cell signaling and maintains the balance between activation and inhibition. Lyn thus functions as a rheostat that modulates signaling rather than as a binary on-off switch.

Lyn (singer)

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Lee Se-jin (born on Seoul, South Korea on 9 November 1981) is a South Korean R&B singer known professionally as Lyn. She has released ten full albums to date.

Biography

Lyn was born in Seoul, South Korea on 9 November 1981. She graduated from Seoul High School and attended University of Seoul.

Career

Lyn was first scouted by an agency because of her voice and from there, she first made her debut under her real name, Lee Se-jin, and released an album. The album sold poorly and was barely known. Lyn then took some time off to train vocally. She made a comeback in 2002 under the name Lyn with her supposedly first album Have You Ever Have A Broken Heart?. It was very successful and was able to shoot her up to one of the top R&B female solo singer of the year. After a surprise two years hiatus, Lyn released her second album Can U See The Bright. The album was very successful, surpassing her previous album with her popular single, "사랑했잖아" (Used To Love). Due to its popularity, the song was eventually covered on another successful singer Lee Seung-gi's album, released in late 2006. Lyn released her third album, The Pride of the Morning, on March 7, 2007, and sold 15,358 copies in that month, placing second in the Music Industry Association of Korea's monthly chart. Again, it was a success and was once again reclaim her title as one of the best R&B female singer. Overall her album sold 25,171 copies. Lyn then released more albums afterwards, and did not become very successful, but in 2009 she made a comeback with her 5th album called 'Let Go, Let In, It's a New Day'. In early 2012, she released her 7th album title 'Love Fiction'.

Lynn (name)

Lynn or Lynne is a surname and given name in English speaking countries.

Surname

It has a number of separate derivations:

The earliest recorded instance of the surname is Aedricus de Lenna of King's Lynn (1177).

Given name

As a given name, Lynn is predominantly female. Now it is more popular as a middle name than as a first name. It is also popular as a suffix for female first names, such as Madalyn/Madalynn, Jocelyn/Jocelynn, Ashlyn/Ashlynn and Emmalyn/Emmalynn. In the year 2013, only 90 girls were given the name Lynn in the United States (variant spellings not included), according to Social Security's "Beyond The Top 1000" name lists, available for download on their website.

Conclusion (music)

In music, the conclusion is the ending of a composition and may take the form of a coda or outro.

Pieces using sonata form typically use the recapitulation to conclude a piece, providing closure through the repetition of thematic material from the exposition in the tonic key. In all musical forms other techniques include "altogether unexpected digressions just as a work is drawing to its close, followed by a return...to a consequently more emphatic confirmation of the structural relations implied in the body of the work."

For example:

Facebook features

Facebook is a social network service website launched on February 4, 2004. This is a list of software and technology features that can be found on the Facebook website.

Facebook structure

News Feed

On September 6, 2006, Ruchi Sanghvi announced a new home page feature called News Feed. Originally, when users logged into Facebook, they were presented with a customizable version of their own profile. The new layout, by contrast, created an alternative home page in which users saw a constantly updated list of their friends' Facebook activity. News Feed highlights information that includes profile changes, upcoming events, and birthdays, among other updates. This has enabled spammers and other users to manipulate these features by creating illegitimate events or posting fake birthdays to attract attention to their profile or cause. News Feed also shows conversations taking place between the walls of a user's friends. An integral part of the News Feed interface is the Mini Feed, a news stream on the user's profile page that shows updates about that user. Unlike in the News Feed, the user can delete events from the Mini Feed after they appear so that they are no longer visible to profile visitors. In 2011 Facebook updated the News Feed to show top stories and most recent stories in one feed, and the option to highlight stories to make them top stories, as well as to un-highlight stories. In response to users' criticism, Facebook later updated the News Feed to allow users to view recent stories first.

Tag (game)

Tag (also known as it, tip you're it or tig [in regions of Britain], and many other names) is a playground game that involves one or more players chasing other players in an attempt to "tag" or touch them, usually with their hands. There are many variations; most forms have no teams, scores, or equipment. Usually when a person is tagged, the tagger says, "Tag, you're it".

Basic rules

A group of players (two or more) decide who is going to be "it", often using a counting-out game such as eeny, meeny, miny, moe. The player selected to be "it" then chases the others, attempting to get close enough to "tag" one of them (touching them with a hand) while the others try to escape. A tag makes the tagged player "it" - in some variations, the previous "it" is no longer "it" and the game can continue indefinitely while in others, both players remain "it" and the game ends when all players have become "it".

There are many variants which modify the rules for team play, or place restrictions on tagged players' behavior. A simple variation makes tag an elimination game, so those tagged drop out of play. Some variants have a rule preventing a player from tagging the person who has just tagged them (known as "no tags-back", "no returns", or "can't tag your master").

Hayate

Hayate (疾風) is a Japanese word which can mean "fresh breeze", although in that sense, it is usually pronounced as shippū (しっぷう). Hayate can also refer to:

Characters