Off!

Off! is an American hardcore punk supergroup, formed in Los Angeles in 2009.

History

Off! was formed in Los Angeles, California in late 2009 by Circle Jerks/Black Flag singer Keith Morris, Burning Brides frontman Dimitri Coats, Redd Kross bassist Steven Shane McDonald, and Rocket From The Crypt/Hot Snakes drummer Mario Rubalcaba. The idea to form the band came after Coats had worked as producer on a Circle Jerks album which fell apart. During that time, Coats and Morris had written several songs together which they used to start Off!. The group made its live debut at the 2010 South By Southwest Music Festival in Austin, Texas. Off!'s first Los Angeles show featured an original art installation by Raymond Pettibon at a downtown warehouse space.

The first release by Off! is a 7" vinyl EP called 1st EP, which debuted on October 13, 2010. That EP, along with three more EPs, were later released as a four 7" vinyl box set entitled First Four EPs on December 14, 2010. The collection contains sixteen songs and features artwork by Raymond Pettibon.

Proposed top-level domain

The Domain Name System of the Internet consists of a set of top-level domains which constitute the root domain of the hierarchical name space and database. In the growth of the Internet, it became desirable to expand the set of initially six generic top-level domains in 1984. As a result new top-level domain names have been proposed for implementation by ICANN. Such proposals included a variety of models ranging from adoption of policies for unrestricted gTLDs that could be registered by anyone for any purpose, to chartered gTLDs for specialized uses by specialized organizations. In October 2000, ICANN published a list of proposals for top-level domain strings it had received.

Geographic proposals

MED28

Mediator of RNA polymerase II transcription subunit 28 is an enzyme that in humans is encoded by the MED28 gene. It forms part of the Mediator complex.

Function

Subunit Med28 of the Mediator may function as a scaffolding protein within Mediator by maintaining the stability of a submodule within the head module, and components of this submodule act together in a gene-regulatory programme to suppress smooth muscle cell differentiation. Thus, mammalian Mediator subunit Med28 functions as a repressor of smooth muscle-cell differentiation, which could have implications for disorders associated with abnormalities in smooth muscle cell growth and differentiation, including atherosclerosis, asthma, hypertension, and smooth muscle tumours.

Interactions

MED28 has been shown to interact with Merlin,Grb2 and MED26.

See also

References

This article incorporates text from the public domain Pfam and InterPro IPR021640

Further reading

MED6

Mediator of RNA polymerase II transcription subunit 6 is one of the subunits of the Mediator complex. It is an enzyme that in humans is encoded by the MED6 gene.

Protein family

This family of proteins represent the transcriptional mediator protein subunit 6 that is required for activation of many RNA polymerase II promoters and which are conserved from yeast to humans.

Interactions

MED6 has been shown to interact with:

References

Further reading

External links

This article incorporates text from the public domain Pfam and InterPro IPR007018