Transmembrane channel-like 6
Identifiers
Symbols TMC6; EV1; EVER1; EVIN1; LAK-4P
External IDs OMIM: 605828 MGI: 1098686 HomoloGene: 5258 GeneCards: TMC6 Gene
Orthologs
Species Human Mouse
Entrez 11322 217353
Ensembl ENSG00000141524 ENSMUSG00000025572
UniProt Q7Z403 Q7TN60
RefSeq (mRNA) NM_001127198.1 NM_145439.2
RefSeq (protein) NP_001120670.1 NP_663414.3
Location (UCSC) Chr 17:
76.11 – 76.13 Mb		 Chr 11:
117.63 – 117.64 Mb
PubMed search [1] [2]
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Transmembrane channel-like protein 6 is a protein that in humans is encoded by the TMC6 gene.[1][2] In vivo, TMC6 and its homolog TMC8, interact and form a complex with the zinc transporter 1 (SLC30A1) and localize mostly to the endoplasmic reticulum, but also to the nuclear membrane and Golgi apparatus.[3]

Inactivating mutations in TMC6 or TMC8 have been implicated as the genetic cause of the rare skin disorder epidermodysplasia verruciformis[3], which is characterized by abnormal susceptibility to human papillomaviruses (HPVs) of the skin resulting in the growth of scaly macules and papules, particularly on the hands and feet.

References [link]

  1. ^ Ramoz N, Rueda LA, Bouadjar B, Montoya LS, Orth G, Favre M (Nov 2002). "Mutations in two adjacent novel genes are associated with epidermodysplasia verruciformis". Nat Genet 32 (4): 579–81. DOI:10.1038/ng1044. PMID 12426567. 
  2. ^ "Entrez Gene: TMC6 transmembrane channel-like 6". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11322. 
  3. ^ a b Lazarczyk, M; C Pons, JA Mendoza, P Cassonnet, Y Jacob, M Favre (2008-01-21). "Regulation of cellular zinc balance as a potential mechanism of EVER-mediated protection against pathogenesis by cutaneous oncogenic human papillomaviruses". The Journal of Experimental Medicine 205 (1): 35–42. DOI:10.1084/jem.20071311. PMC 2234378. PMID 18158319. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2234378. Retrieved 2008-09-19. 

Further reading [link]



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Transition metal
Other
TMC6 · TMC8 · SLC30A1 · SLC39A4
Electrolyte

M: NUT

cof, enz, met

drug(A8/11/12)

https://wn.com/TMC6

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