Äetsä is a former municipality of southwestern Finland. The municipality was founded on 1981 when municipalities of Keikyä and Kiikka were consolidated to a single municipality.
On 1 January 2009, it was consolidated with the municipalities of Vammala and Mouhijärvi to form a new city of Sastamala.
Äetsä was located in the western Pirkanmaa region, and was part of the former (1997 to 2010) province of Western Finland.
The municipality had a population of 4,797 (November 30, 2008) and covered an area of 241.95 square kilometres (93.42 sq mi), of which 8.38 km2 (3.24 sq mi) was water. The population density was 20.54 inhabitants per square kilometre (53.2/sq mi).
The municipality was unilingually Finnish.
Coordinates: 61°17′05″N 022°41′50″E / 61.28472°N 22.69722°E
Protein C-ets-2 is a protein that in humans is encoded by the ETS2 gene. The protein encoded by this gene belongs to the ETS family of transcription factors.
ETS2 has been shown to interact with:
Protein C-ets-1 is a protein that in humans is encoded by the ETS1 gene. The protein encoded by this gene belongs to the ETS family of transcription factors.
There are 28 ETS genes in humans and 27 genes – in mice. They bind the DNA via their winged-helix-turn-helix DNA binding motif known as the Ets domain that specifically recognizes DNA sequences that contain a GGAA/T core element. However, Ets proteins differ significantly in their preference for the sequence flanking the GGAA/T core motif. For instance, the consensus sequence for Ets1 is PuCC/a-GGAA/T-GCPy. On the other hand, many natural Ets1-responsive GGAA/T elements differ from this consensus sequence. The later suggests that several other transcription factors may facilitate Ets1 binding to unfavorable DNA sequences.
Ets1 binds to DNA as a monomer. Phosphorylation of serine residues of the C-terminal domain (in the nucleotide sequence they belong to exon VII) known as autoinhibition makes Ets1 inactive. There are several ways to activate Ets1. First, Ets1 can be dephosphorylated. Second, two Ets1 can be activated If two Ets molecules homodimerize. The homodimerization occurs if DNA binding sites are present in the correct orientation and spacing. Thus, the exact layout of binding sites within an enhancer or promoter segment to either relieve or allow autoinhibition of Ets1 to occur may strongly influence whether or not Ets1 actually binds to particular site. Third, Ets1 can be activated by Erk2 and Ras at Thr38. The truncated isoform cannot be phosphorylated by the Erk2. It is localized in the cytoplasm and acts as a dominant negative isoform. Contrary, another isoform that misses exon VII is constitutively active. Many Ras responsive genes harbor combinatorial Ets/AP1 recognition motifs through which Ets1 and AP1 synergistically activate transcription when stimulated by Ras.
Her name is Noel
I have a dream about her
She rings my bell
I got gym class in half an hour
Oh how she rocks
In Keds and tube socks
But she doesn't know who I am
And she doesn't give a damn about me
Cause I'm just a teenage dirtbag baby
Yeah I'm just a teenage dirtbag baby
Listen to Iron Maiden baby with me
Her boyfriend's a dick
And he brings a gun to school
And he'd sI'mply kick
My ass if he knew the truth
He lives on my block
And he drives an Iroc
But he doesn't know who I am
And he doesn't give a damn about me
Cause I'm just a teenage dirtbag baby
Yeah I'm just a teenage dirtbag baby
Listen to Iron Maiden baby with me
Yeeah dirtbag, no she doesn't know what she's missin
Yeeah dirtbag, no she doesn't know what she's missin
Man I feel like mold
It's prom night and I am lonely
Low and behold
She's walking over to me
This must be fake
My lip starts to shake
How does she know who I am
And why does she give a damn about
I've got two tickets to Iron Maiden baby
Come with me Friday, don't say maybe
I'm just a teenage dirtbag baby like you
Yeeah dirtbag, no she doesn't know what she's missin