ESCRT
The endosomal sorting complexes required for transport (ESCRT) machinery is made up of cytosolic protein complexes, known as ESCRT-0, ESCRT-I, ESCRT-II, and ESCRT-III. Together with a number of accessory proteins, these ESCRT complexes enable a unique mode of membrane remodeling that results in membranes bending/budding away from the cytoplasm. These ESCRT components have been isolated and studied in a number of organisms including yeast and humans.
The ESCRT machinery plays a vital role in a number of cellular processes including multivesicular body (MVB) biogenesis, cellular abscission, and viral budding. Multivesicular body (MVB) biogenesis is a process in which ubiquitin tagged proteins enter organelles called endosomes via the formation of vesicles. This process is essential for cells to destroy misfolded and damaged proteins. Without ESCRT machinery, these proteins can build up and lead to neurodegenerative disease. For example, abnormalities in ESCRT-III components can lead to neurological disorders such as hereditary spastic paraplegia (HSP). Cellular abscission, the process by which the membrane connecting two daughter cells is cleaved, is also mediated by ESCRT machinery. Without the ESCRT complexes, daughter cells could not separate and abnormal cells containing twice the amount of DNA would be generated. These cells would inevitably be destroyed through a process known as apoptosis. Lastly, viral budding, or the process by which specific types of viruses exit cells, may not occur in the absence of ESCRT machinery. This would inevitably prevent viruses from spreading from cell to cell.
Podcasts:
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by Insane Clown Posse
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by ICP (Insane Clown Posse)
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by I.C.P.
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by Status Quo
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by Lucia
Who Asked You
by: Insane Clown PosseDrank my last cup of dead body stew
Paint my face, creep up and say BOO!
Nobody knows what I'm about
Walk around town with my guts hanging out
Chewin on toes, fuckin dead hoes
Bark at the moon everytime the wind blows
Why do I do the things that I do?
Who are you? Fuck you, and fuck Jerry Lou too
Fucked your mother at the Motel 8
Fingers in her booty, strawberry shake
Daddy walks in and see the sick clown
Moving his butt-cheeks up and down
Nate the Mack and Jump Steady
Rude Boy, Regis, Kathy Lee
I make rap rhymes and make quick bucks
And everybody sucks my nuts, shucks
Fuck Jazzy Jeff, fuck Jack Jones
Fuck Jazzy Jiff Jeff Jimmy Jack Jones
Why do we do the things that we do?
Who the motherfuck asked you, uh?
Why do we do the things that we do?
Roses ain't red and violet's ain't blue
Why do we do the things that we do?
Wicked rhymes, wicked times, you too
Never had life, always been dead
Gotta metal plate in the back of my head
Lemon drops, lick lollipops
I fuck redneck bitches at truck stops
Clown cutters, much clown luv
Found a body in the bathtub, mmm grub
Fuck the police, fuck Ebin Price
Fuck cop pork chop jiffy pop cops
Grew another head and I had it lopped off
But we still cool, what's up, (what's up, dawg)
Tock-ticky-tock I pack a pig clock
My dingaling swings when I run down the block
No, I don't sing in a rock band
"Gotta smoke, dude, what's up, man"
Fuck John Wayne, fuck Wayne Newton
Fuck two-snooting John Hootin nanny pooping
Why do we do the things that we do?