ESAT-6

ESAT-6, the 6 kDa early secretory antigenic target produced by Mycobacterium tuberculosis, is a secretory protein and potent T cell antigen. It is used in tuberculosis diagnosis by the whole blood interferon γ test QuantiFERON-TB Gold, in conjunction with CFP-10 and TB7.7.

ESAT-6 has been shown to directly bind to the TLR2 receptor, inhibiting downstream signal transduction.

See also

  • CFP-10
  • TB7.7
  • References

  • "Entrez gene".
  • Pathak SK, Basu S, Basu KK, Banerjee A, Pathak S, Bhattacharyya A, Kaisho T, Kundu M, Basu J (June 2007). "Direct extracellular interaction between the early secreted antigen ESAT-6 of Mycobacterium tuberculosis and TLR2 inhibits TLR signaling in macrophages.". Nat. Immunol. 8 (6): 610–8. doi:10.1038/ni1468. PMID 17486091.

  • Podcasts:

    PLAYLIST TIME:

    We Used To

    by: Dolly Parton

    Mmm....
    We used to walk through fields of green
    We used to sit by clear blue streams
    We used to be so happy
    Me and you
    We used to do such silly things
    We used to make love in the rain
    We used to
    Yes, we used to
    Then you went away
    Leaving me with the memories we made
    Memories of those sweet yesterdays
    Spent with you
    Spent with you
    And even though you're gone
    I still think so often of you
    And the things that we no longer do
    Like we used to
    Oh we used to
    We used to be so much in love
    We used to kiss and hold and touch
    We used to find so many things to do
    We used to laugh and plan and dream
    We used to own the world it seemed
    We used to
    Yes we used to
    Then you went away
    Leaving me with the memories we made
    Memories of those sweet yesterdays
    Spent with you
    Spent with you
    Oh and even though you're gone
    I still think so often of you
    And the things that we no longer do
    Like we used to
    Oh we used to
    La...mmm....




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