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ERBB receptor feedback inhibitor 1 is a protein that in humans is encoded by the ERRFI1 gene.[1][2][3][4][5]
MIG6 is a cytoplasmic protein whose expression is upregulated with cell growth (Wick et al., 1995). It shares significant homology with the protein product of rat gene-33, which is induced during cell stress and mediates cell signaling (Makkinje et al., 2000; Fiorentino et al., 2000).[supplied by OMIM][5]
Interactions [link]
ERRFI1 has been shown to interact with Stratifin[6] and CDC42.[1]
References [link]
- ^ a b Makkinje A, Quinn DA, Chen A, Cadilla CL, Force T, Bonventre JV, Kyriakis JM (Jul 2000). "Gene 33/Mig-6, a transcriptionally inducible adapter protein that binds GTP-Cdc42 and activates SAPK/JNK. A potential marker transcript for chronic pathologic conditions, such as diabetic nephropathy. Possible role in the response to persistent stress". J Biol Chem 275 (23): 17838–17847. DOI:10.1074/jbc.M909735199. PMID 10749885.
- ^ Chrapkiewicz NB, Davis CM, Chu DT, Caldwell CM, Granner DK (Oct 1989). "Rat gene 33: analysis of its structure, messenger RNA and basal promoter activity". Nucleic Acids Res 17 (16): 6651–6667. DOI:10.1093/nar/17.16.6651. PMC 318357. PMID 2780291. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=318357.
- ^ Fiorini M, Ballaro C, Sala G, Falcone G, Alema S, Segatto O (Sep 2002). "Expression of RALT, a feedback inhibitor of ErbB receptors, is subjected to an integrated transcriptional and post-translational control". Oncogene 21 (42): 6530–6539. DOI:10.1038/sj.onc.1205823. PMID 12226756.
- ^ Fiorentino L, Pertica C, Fiorini M, Talora C, Crescenzi M, Castellani L, Alema S, Benedetti P, Segatto O (Oct 2000). "Inhibition of ErbB-2 mitogenic and transforming activity by RALT, a mitogen-induced signal transducer which binds to the ErbB-2 kinase domain". Mol Cell Biol 20 (20): 7735–7750. DOI:10.1128/MCB.20.20.7735-7750.2000. PMC 86354. PMID 11003669. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=86354.
- ^ a b "Entrez Gene: ERRFI1 ERBB receptor feedback inhibitor 1". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=54206.
- ^ Benzinger, Anne; Muster Nemone, Koch Heike B, Yates John R, Hermeking Heiko (Jun. 2005). "Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer". Mol. Cell Proteomics (United States) 4 (6): 785–795. DOI:10.1074/mcp.M500021-MCP200. ISSN 1535-9476. PMID 15778465.
Further reading [link]
- Zhang YW, Vande Woude GF (2007). "Mig-6, signal transduction, stress response and cancer". Cell Cycle 6 (5): 507–13. DOI:10.4161/cc.6.5.3928. PMID 17351343.
- Wick M, Bürger C, Funk M, Müller R (1995). "Identification of a novel mitogen-inducible gene (mig-6): regulation during G1 progression and differentiation". Exp. Cell Res. 219 (2): 527–535. DOI:10.1006/excr.1995.1261. PMID 7641805.
- Hackel PO, Gishizky M, Ullrich A (2002). "Mig-6 is a negative regulator of the epidermal growth factor receptor signal". Biol. Chem. 382 (12): 1649–1662. DOI:10.1515/BC.2001.200. PMID 11843178.
- Tsunoda T, Inokuchi J, Baba I et al. (2002). "A novel mechanism of nuclear factor kappaB activation through the binding between inhibitor of nuclear factor-kappaBalpha and the processed NH(2)-terminal region of Mig-6". Cancer Res. 62 (20): 5668–71. PMID 12384522.
- Saarikoski ST, Rivera SP, Hankinson O (2002). "Mitogen-inducible gene 6 (MIG-6), adipophilin and tuftelin are inducible by hypoxia". FEBS Lett. 530 (1–3): 186–190. DOI:10.1016/S0014-5793(02)03475-0. PMID 12387890.
- Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
- Anastasi S, Fiorentino L, Fiorini M et al. (2003). "Feedback inhibition by RALT controls signal output by the ErbB network". Oncogene 22 (27): 4221–4234. DOI:10.1038/sj.onc.1206516. PMID 12833145.
- Ota T, Suzuki Y, Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. DOI:10.1038/ng1285. PMID 14702039.
- Gerhard DS, Wagner L, Feingold EA et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. DOI:10.1101/gr.2596504. PMC 528928. PMID 15489334. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
- Xu D, Makkinje A, Kyriakis JM (2005). "Gene 33 is an endogenous inhibitor of epidermal growth factor (EGF) receptor signaling and mediates dexamethasone-induced suppression of EGF function". J. Biol. Chem. 280 (4): 2924–2933. DOI:10.1074/jbc.M408907200. PMID 15556944.
- Keeton AB, Messina JL (2005). "Modulation of Elk-dependent-transcription by Gene33". J. Cell. Biochem. 94 (6): 1190–1198. DOI:10.1002/jcb.20370. PMID 15696545.
- Benzinger A, Muster N, Koch HB et al. (2005). "Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer". Mol. Cell Proteomics 4 (6): 785–795. DOI:10.1074/mcp.M500021-MCP200. PMID 15778465.
- Anastasi S, Sala G, Huiping C et al. (2005). "Loss of RALT/MIG-6 expression in ERBB2-amplified breast carcinomas enhances ErbB-2 oncogenic potency and favors resistance to Herceptin". Oncogene 24 (28): 4540–4548. DOI:10.1038/sj.onc.1208658. PMID 15856022.
- Ballarò C, Ceccarelli S, Tiveron C et al. (2006). "Targeted expression of RALT in mouse skin inhibits epidermal growth factor receptor signalling and generates a Waved-like phenotype". EMBO Rep. 6 (8): 755–761. DOI:10.1038/sj.embor.7400458. PMC 1369136. PMID 16007071. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1369136.
- Gregory SG, Barlow KF, McLay KE et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature 441 (7091): 315–321. DOI:10.1038/nature04727. PMID 16710414.
- Zhang YW, Staal B, Su Y et al. (2007). "Evidence that MIG-6 is a tumor-suppressor gene". Oncogene 26 (2): 269–276. DOI:10.1038/sj.onc.1209790. PMID 16819504.
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