ERBB4
Receptor tyrosine-protein kinase erbB-4 is an enzyme that in humans is encoded by the ERBB4 gene. Alternatively spliced variants that encode different protein isoforms have been described; however, not all variants have been fully characterized.
Function
Receptor tyrosine-protein kinase erbB-4 is a receptor tyrosine kinase that is a member of the epidermal growth factor receptor subfamily. ERBB4 is a single-pass type I transmembrane protein with multiple furin-like cysteine rich domains, a tyrosine kinase domain, a phosphotidylinositol-3 kinase binding site and a PDZ domain binding motif. The protein binds to and is activated by neuregulins-2 and -3, heparin-binding EGF-like growth factor and betacellulin. Ligand binding induces a variety of cellular responses including mitogenesis and differentiation. Multiple proteolytic events allow for the release of a cytoplasmic fragment and an extracellular fragment.
Clinical significance
Mutations in this gene have been associated with cancer. Other single-nucleotide polymorphisms and a risk haplotype have been linked to schizophrenia.Single-nucleotide polymorphisms in ERBB4 have also been found in a study of patients with familial Amyotrophic lateral sclerosis type 19
Podcasts:
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by Divine Comedy
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by The Divine Comedy
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by Eiffel 65
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by Greenhouse Effect
Europop
by: Divine ComedyHello
What would you like to know?
What would you like to hear?
What if I just disappear inside myself?
Hello
What would you like to know?
Who would you like to see?
Who would you like me to be, if not myself?
And the Europop
Makes me dizzy
And I just can't stop
'Til it's finished
And I don't know what
You find funny 'bout the Europop
And the love of money
Hello
Where is it cool to go?
When is it cool to leave?
What is it cool to breathe inside myself?
Hello
Don't tell me what I already know
Don't show me what I've already seen
Don't take me where I've already been
Inside myself
And the Europop
Makes me dizzy
And I just can't stop
'Til it's finished
And I don't know what
You find funny 'bout the Europop
And the love of money
Financial gain
Is a very pleasant thing
But the transitory pleasure that it brings
Counts for nothing!
What is there left to know?
What is there left to say?
Nothing
And the Europop
Makes me dizzy
And I just can't stop
'Til it's finished
And I don't know what
You find funny 'bout the Europop
And the love of money
And I thank God
That you're aware
Oh thank God
That you're aware
Of the earth and of the air
And of the girls making like they don't care
But they are blessed
And you are cursed
With the conscience of a universe
Of the mind and of the soul
Of reduction science digging itself a hole
And I thank God that you're aware
And thank your God we're all aware
It's taken time but I'll think you'll find