ENSA (gene)

Alpha-endosulfine is a protein that in humans is encoded by the ENSA gene.

The protein encoded by this gene belongs to a highly conserved cAMP-regulated phosphoprotein (ARPP) family. This protein was identified as an endogenous ligand for the sulfonylurea receptor, ABCC8/SUR1. ABCC8 is the regulatory subunit of the ATP-sensitive potassium (KATP) channel, which is located on the plasma membrane of pancreatic beta cells and plays a key role in the control of insulin release from pancreatic beta cells. This protein is thought to be an endogenous regulator of KATP channels. In vitro studies have demonstrated that this protein modulates insulin secretion through the interaction with KATP channel, and this gene has been proposed as a candidate gene for type 2 diabetes. At least eight alternatively spliced transcript variants encoding distinct isoforms have been observed.

References

Further reading

Gene

A gene is a locus (or region) of DNA that encodes a functional RNA or protein product, and is the molecular unit of heredity. The transmission of genes to an organism's offspring is the basis of the inheritance of phenotypic traits. Most biological traits are under the influence of polygenes (many different genes) as well as the gene–environment interactions. Some genetic traits are instantly visible, such as eye colour or number of limbs, and some are not, such as blood type, risk for specific diseases, or the thousands of basic biochemical processes that comprise life.

Genes can acquire mutations in their sequence, leading to different variants, known as alleles, in the population. These alleles encode slightly different versions of a protein, which cause different phenotype traits. Colloquial usage of the term "having a gene" (e.g., "good genes," "hair colour gene") typically refers to having a different allele of the gene. Genes evolve due to natural selection or survival of the fittest of the alleles.

Eugene (given name)

Eugene is a common (masculine) first name that comes from the Greek εὐγενής (eugenēs), "noble", literally "well-born", from εὖ (eu), "well" and γένος (genos), "race, stock, kin".Gene is a common shortened form. The feminine variant is Eugenia or Eugénie.

Male foreign-language variants include:

Notable people

Christianity

Military

Gene (novel)

Gene is a thriller novel by Stel Pavlou (born 1970), published in 2005 in England by Simon & Schuster. It is published in several languages with some title changes. The Italian edition has the title La Conspirazione del Minotauro (The Minotaur Conspiracy). The novel is about a fictional New York detective, James North, who in the process of hunting down a criminal, uncovers a genetics experiment to unlock past lives through genetic memory, therefore achieving a kind of immortality. In so doing North discovers his own origins, that of a soldier from the Trojan War who is reincarnated seven times through history, forced to confront his nemesis each time, all for the loss of his one true love.

Characters

Cyclades (born circa 1300 BC)

Incarnations of Cyclades

Athanatos (born circa 1500 BC)

Incarnations of Athanatos

Entertainments National Service Association

The Entertainments National Service Association or ENSA was an organisation set up in 1939 by Basil Dean and Leslie Henson to provide entertainment for British armed forces personnel during World War II. ENSA operated as part of the Navy, Army and Air Force Institutes. It was superseded by Combined Services Entertainment (CSE) which now operates as part of the Services Sound and Vision Corporation (SSVC).

The first big wartime variety concert organized by ENSA was broadcast by the BBC to the Empire and local networks from RAF Hendon in north London on 17 October 1939 and Adelaide Hall, The Western Brothers and Mantovani were amongst those entertainers appearing on the bill. A rare Newsreel of this concert showing Adelaide Hall singing We're Going to Hang out the Washing on the Siegfried Line accompanied by Mantovani and his orchestra still exists.

Members

Many well-known stars have performed in ENSA, including Robert Rietty, Gracie Fields, George Formby, Wilfrid Brambell, Joyce Grenfell, Adelaide Hall, Paul Scofield, Rebecca Cantwell, Dora Bryan and Vera Lynn.

ENSA (disambiguation)

ENSA may refer to: