EMR3
EGF-like module-containing mucin-like hormone receptor-like 3 is a protein encoded by the ADGRE3 gene. EMR3 is a member of the adhesion GPCR family. Adhesion GPCRs are characterized by an extended extracellular region often possessing N-terminal protein modules that is linked to a TM7 region via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain.
EMR3 expression is restricted to monocytes/macrophages, myeloid dendritic cells, and mature granulocytes in human. Transcription of the EMR3 gene results in two alternative spliced forms: a surface protein with extracellular, 7TM, and intracellular domains as well as a truncated soluble form of only the extracellular domain. Mice, next to Emr2, lack the Emr3 gene.
Function
The protein may play a role in myeloid-myeloid interactions during immune and inflammatory responses.
Ligands
A potential ligand of EMR3 likely is expressed on human macrophage and activated neutrophils.
References
External links
Podcasts:
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by Ayah Marar
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by Ayah Marar
Unstoppable
by: Ayah MararThere's nothing left for us here
Taking it far as our eyes can see
I'm saying no to the fear
Taking a chance we like what we hear
Skin feels hot to touch, the light is bouncing
Off my face, the rush
And the sun will heat me up, temperature rising
Just can't give enough
And I'm out of control, ready to go
Trust me we're never scared
And I'm giving it all, so just act like you know
Trust me on this I swear
I'm unstoppable yeah
Unstoppable
I'm unstoppable yeah
Unstoppable
I'm unstoppable yeah
Unstoppable
I'm unstoppable yeah
Unstoppable
Calling you out, I'm I'm calling you
Calling you out, I'm I'm calling you
Calling you out, I'm I'm calling you
Calling you out, I'm I'm calling you
Calling you out, I'm I'm calling you
Calling you out, I'm I'm calling you
Sailing through the atmosphere
Chasing the sun when the skies are clear
Programmed to follow my ears
Ready to go, only got one gear
Skin feels hot to touch, the light is bouncing
Off my face, the rush
And the sun will heat me up, temperature rising
Just can't get enough
And I'm out of control, ready to go
Trust me we're never scared
And I'm giving it all, so just act like you know
Trust me on this I swear
I'm unstoppable yeah
Unstoppable
I'm unstoppable yeah
Unstoppable
I'm unstoppable yeah
Unstoppable
I'm unstoppable yeah
Unstoppable
Oh oh...
We unstoppable, we unstoppable, we unstoppable oh oh oh
We unstoppable, we unstoppable, we unstoppable oh oh oh
We unstoppable, we unstoppable, we unstoppable oh oh oh
We unstoppable, we unstoppable, we unstoppable
Calling you out, I'm I'm calling you
Calling you out, I'm I'm calling you
Calling you out, I'm I'm calling you
Calling you out, I'm I'm calling you
Calling you out, I'm I'm calling you
Calling you out, I'm I'm calling you
Calling you out, I'm I'm calling you
Calling you out, I'm I'm calling you