EMR2
EGF-like module-containing mucin-like hormone receptor-like 2 also known as CD312 (cluster of differentiation 312) is a protein encoded by the ADGRE2 gene. EMR2 is a member of the adhesion GPCR family. Adhesion GPCRs are characterized by an extended extracellular region often possessing N-terminal protein modules that is linked to a TM7 region via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain.
EMR2 is expressed by monocytes/macrophages, dendritic cells and all types of granulocytes. In the case of EMR2 the N-terminal domains consist of alternatively spliced epidermal growth factor-like (EGF-like) domains. EMR2 is closely related to CD97 with 97% amino-acid identity in the EGF-like domains. The N-terminal fragment (NTF) of EMR2 presents 2-5 EGF-like domains in human. Mice lack the Emr2 gene. This gene is closely linked to the gene encoding EGF-like molecule containing mucin-like hormone receptor 3 EMR3 on chromosome 19.
Ligand
Like the related CD97 protein, the fourth EGF-like domain of EMR2 binds chondroitin sulfate B to mediate cell attachment. However, unlike CD97 EMR2 does not interact with the complement regulatory protein, decay accelerating factor CD55, and indicating that these very closely related proteins likely have nonredundant functions.
Podcasts:
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by Ayah Marar
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by Ayah Marar
Unstoppable
by: Ayah MararThere's nothing left for us here
Taking it far as our eyes can see
I'm saying no to the fear
Taking a chance we like what we hear
Skin feels hot to touch, the light is bouncing
Off my face, the rush
And the sun will heat me up, temperature rising
Just can't give enough
And I'm out of control, ready to go
Trust me we're never scared
And I'm giving it all, so just act like you know
Trust me on this I swear
I'm unstoppable yeah
Unstoppable
I'm unstoppable yeah
Unstoppable
I'm unstoppable yeah
Unstoppable
I'm unstoppable yeah
Unstoppable
Calling you out, I'm I'm calling you
Calling you out, I'm I'm calling you
Calling you out, I'm I'm calling you
Calling you out, I'm I'm calling you
Calling you out, I'm I'm calling you
Calling you out, I'm I'm calling you
Sailing through the atmosphere
Chasing the sun when the skies are clear
Programmed to follow my ears
Ready to go, only got one gear
Skin feels hot to touch, the light is bouncing
Off my face, the rush
And the sun will heat me up, temperature rising
Just can't get enough
And I'm out of control, ready to go
Trust me we're never scared
And I'm giving it all, so just act like you know
Trust me on this I swear
I'm unstoppable yeah
Unstoppable
I'm unstoppable yeah
Unstoppable
I'm unstoppable yeah
Unstoppable
I'm unstoppable yeah
Unstoppable
Oh oh...
We unstoppable, we unstoppable, we unstoppable oh oh oh
We unstoppable, we unstoppable, we unstoppable oh oh oh
We unstoppable, we unstoppable, we unstoppable oh oh oh
We unstoppable, we unstoppable, we unstoppable
Calling you out, I'm I'm calling you
Calling you out, I'm I'm calling you
Calling you out, I'm I'm calling you
Calling you out, I'm I'm calling you
Calling you out, I'm I'm calling you
Calling you out, I'm I'm calling you
Calling you out, I'm I'm calling you
Calling you out, I'm I'm calling you