Function

Function may refer to:

Math, computing and engineering

Music

Other uses

See also

Minkowski's question mark function

In mathematics, the Minkowski question mark function (or the slippery devil's staircase), denoted by ?(x), is a function possessing various unusual fractal properties, defined by Hermann Minkowski (1904, pages 171–172). It maps quadratic irrationals to rational numbers on the unit interval, via an expression relating the continued fraction expansions of the quadratics to the binary expansions of the rationals, given by Arnaud Denjoy in 1938. In addition, it maps rational numbers to dyadic rationals, as can be seen by a recursive definition closely related to the Stern–Brocot tree.

Definition

If is the continued fraction representation of an irrational number x, then

whereas:

If is a continued fraction representation of a rational number x, then

Intuitive explanation

To get some intuition for the definition above, consider the different ways of interpreting an infinite string of bits beginning with 0 as a real number in [0,1]. One obvious way to interpret such a string is to place a binary point after the first 0 and read the string as a binary expansion: thus, for instance, the string 001001001001001001001001... represents the binary number 0.010010010010..., or 2/7. Another interpretation views a string as the continued fraction [0; a₁, a₂, … ], where the integers a_i are the run lengths in a run-length encoding of the string. The same example string 001001001001001001001001... then corresponds to [0; 2, 1, 2, 1, 2, 1, …] = √3 − 1/2. If the string ends in an infinitely long run of the same bit, we ignore it and terminate the representation; this is suggested by the formal "identity":

Structural functionalism

Structural functionalism, or simply functionalism, is a framework for building theory that sees society as a complex system whose parts work together to promote solidarity and stability. This approach looks at society through a macro-level orientation, which is a broad focus on the social structures that shape society as a whole, and believes that society has evolved like organisms. This approach looks at both social structure and social functions. Functionalism addresses society as a whole in terms of the function of its constituent elements; namely norms, customs, traditions, and institutions. A common analogy, popularized by Herbert Spencer, presents these parts of society as "organs" that work toward the proper functioning of the "body" as a whole. In the most basic terms, it simply emphasizes "the effort to impute, as rigorously as possible, to each feature, custom, or practice, its effect on the functioning of a supposedly stable, cohesive system". For Talcott Parsons, "structural-functionalism" came to describe a particular stage in the methodological development of social science, rather than a specific school of thought. The structural functionalism approach is a macrosociological analysis, with a broad focus on social structures that shape society as a whole.

EMR1

EGF-like module-containing mucin-like hormone receptor-like 1 also known as F4/80 is a protein encoded by the ADGRE1 gene. EMR1 is a member of the adhesion GPCR family. Adhesion GPCRs are characterized by an extended extracellular region often possessing N-terminal protein modules that is linked to a TM7 region via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain.

EMR1 expression in human is restricted to eosinophils and is a specific marker for these cells. The murine homolog of EMR1, F4/80, is a well-known and widely-used marker of murine macrophage populations. The N-terminal fragment (NTF) of EMR1 contains 4-6 Epidermal Growth Factor-like (EGF-like) domains in human and 4-7 EGF-like domains in the mouse.

Function

Utilizing F4/80 knockout mice, Lin et al. showed that F4/80 is not necessary for the development of tissue macrophages but is required for the induction of efferent CD8⁺ regulatory T cells needed for peripheral tolerance.

Clinical significance

Legrand et al. recently demonstrated that EMR1 can serve as a therapeutic target for depletion of these cells in eosinophilic disorders by using afucosylated antibodies.