EMR1
EGF-like module-containing mucin-like hormone receptor-like 1 also known as F4/80 is a protein encoded by the ADGRE1 gene. EMR1 is a member of the adhesion GPCR family. Adhesion GPCRs are characterized by an extended extracellular region often possessing N-terminal protein modules that is linked to a TM7 region via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain.
EMR1 expression in human is restricted to eosinophils and is a specific marker for these cells. The murine homolog of EMR1, F4/80, is a well-known and widely-used marker of murine macrophage populations. The N-terminal fragment (NTF) of EMR1 contains 4-6 Epidermal Growth Factor-like (EGF-like) domains in human and 4-7 EGF-like domains in the mouse.
Function
Utilizing F4/80 knockout mice, Lin et al. showed that F4/80 is not necessary for the development of tissue macrophages but is required for the induction of efferent CD8+ regulatory T cells needed for peripheral tolerance.
Clinical significance
Legrand et al. recently demonstrated that EMR1 can serve as a therapeutic target for depletion of these cells in eosinophilic disorders by using afucosylated antibodies.
Podcasts:
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by Ayah Marar
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by Ayah Marar
Unstoppable
by: Ayah MararThere's nothing left for us here
Taking it far as our eyes can see
I'm saying no to the fear
Taking a chance we like what we hear
Skin feels hot to touch, the light is bouncing
Off my face, the rush
And the sun will heat me up, temperature rising
Just can't give enough
And I'm out of control, ready to go
Trust me we're never scared
And I'm giving it all, so just act like you know
Trust me on this I swear
I'm unstoppable yeah
Unstoppable
I'm unstoppable yeah
Unstoppable
I'm unstoppable yeah
Unstoppable
I'm unstoppable yeah
Unstoppable
Calling you out, I'm I'm calling you
Calling you out, I'm I'm calling you
Calling you out, I'm I'm calling you
Calling you out, I'm I'm calling you
Calling you out, I'm I'm calling you
Calling you out, I'm I'm calling you
Sailing through the atmosphere
Chasing the sun when the skies are clear
Programmed to follow my ears
Ready to go, only got one gear
Skin feels hot to touch, the light is bouncing
Off my face, the rush
And the sun will heat me up, temperature rising
Just can't get enough
And I'm out of control, ready to go
Trust me we're never scared
And I'm giving it all, so just act like you know
Trust me on this I swear
I'm unstoppable yeah
Unstoppable
I'm unstoppable yeah
Unstoppable
I'm unstoppable yeah
Unstoppable
I'm unstoppable yeah
Unstoppable
Oh oh...
We unstoppable, we unstoppable, we unstoppable oh oh oh
We unstoppable, we unstoppable, we unstoppable oh oh oh
We unstoppable, we unstoppable, we unstoppable oh oh oh
We unstoppable, we unstoppable, we unstoppable
Calling you out, I'm I'm calling you
Calling you out, I'm I'm calling you
Calling you out, I'm I'm calling you
Calling you out, I'm I'm calling you
Calling you out, I'm I'm calling you
Calling you out, I'm I'm calling you
Calling you out, I'm I'm calling you
Calling you out, I'm I'm calling you