Eif4e2

Eukaryotic translation initiation factor 4E family member 2

PDB rendering based on 2jgb.

Available structures

Ortholog search: PDBe, RCSB

List of PDB id codes
2JGB, 2JGC

Identifiers

Symbols

EIF4E2; 4E-LP; 4EHP; EIF4EL3; IF4e

External IDs

OMIM: 605895 MGI: 1914440 HomoloGene: 105671 GeneCards: EIF4E2 Gene

Gene Ontology
Molecular function	• RNA cap binding • translation initiation factor activity • protein binding • translation factor activity, nucleic acid binding • ubiquitin protein ligase binding
Cellular component	• cytoplasm • cytosol • mRNA cap binding complex
Biological process	• translation • regulation of translation • cytokine-mediated signaling pathway
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 2:
233.41 – 233.45 Mb

Chr 1:
89.05 – 89.07 Mb

PubMed search

[1]

[2]

Eukaryotic translation initiation factor 4E type 2 is a protein that in humans is encoded by the EIF4E2 gene.^[1]^[2]^[3] It belongs to the eukaryotic translation initiation factor 4E family.

Interactions [link]

EIF4E2 has been shown to interact with ARIH1.^[4]

References [link]

^ Mao M, Fu G, Wu JS, Zhang QH, Zhou J, Kan LX, Huang QH, He KL, Gu BW, Han ZG, Shen Y, Gu J, Yu YP, Xu SH, Wang YX, Chen SJ, Chen Z (Aug 1998). "Identification of genes expressed in human CD34+ hematopoietic stem/progenitor cells by expressed sequence tags and efficient full-length cDNA cloning". Proc Natl Acad Sci U S A 95 (14): 8175–80. DOI:10.1073/pnas.95.14.8175. PMC 20949. PMID 9653160. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=20949.
^ Rom E, Kim HC, Gingras AC, Marcotrigiano J, Favre D, Olsen H, Burley SK, Sonenberg N (Jun 1998). "Cloning and characterization of 4EHP, a novel mammalian eIF4E-related cap-binding protein". J Biol Chem 273 (21): 13104–9. DOI:10.1074/jbc.273.21.13104. PMID 9582349.
^ "Entrez Gene: EIF4E2 eukaryotic translation initiation factor 4E family member 2". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9470.
^ Tan, Nancy G S; Ardley Helen C, Scott Gina B, Rose Stephen A, Markham Alexander F, Robinson Philip A (Nov. 2003). "Human homologue of ariadne promotes the ubiquitylation of translation initiation factor 4E homologous protein, 4EHP". FEBS Lett. (Netherlands) 554 (3): 501–4. DOI:10.1016/S0014-5793(03)01235-3. ISSN 0014-5793. PMID 14623119.

Further reading [link]

Zhang QH, Ye M, Wu XY et al. (2001). "Cloning and Functional Analysis of cDNAs with Open Reading Frames for 300 Previously Undefined Genes Expressed in CD34+ Hematopoietic Stem/Progenitor Cells". Genome Res. 10 (10): 1546–60. DOI:10.1101/gr.140200. PMC 310934. PMID 11042152. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=310934.
Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
Tan NG, Ardley HC, Scott GB et al. (2003). "Human homologue of ariadne promotes the ubiquitylation of translation initiation factor 4E homologous protein, 4EHP". FEBS Lett. 554 (3): 501–4. DOI:10.1016/S0014-5793(03)01235-3. PMID 14623119.
Ota T, Suzuki Y, Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. DOI:10.1038/ng1285. PMID 14702039.
Tee AR, Tee JA, Blenis J (2004). "Characterizing the interaction of the mammalian eIF4E-related protein 4EHP with 4E-BP1". FEBS Lett. 564 (1–2): 58–62. DOI:10.1016/S0014-5793(04)00313-8. PMID 15094042.
Joshi B, Cameron A, Jagus R (2004). "Characterization of mammalian eIF4E-family members". Eur. J. Biochem. 271 (11): 2189–203. DOI:10.1111/j.1432-1033.2004.04149.x. PMID 15153109.
Gerhard DS, Wagner L, Feingold EA et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. DOI:10.1101/gr.2596504. PMC 528928. PMID 15489334. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
Rual JF, Venkatesan K, Hao T et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. DOI:10.1038/nature04209. PMID 16189514.
Okumura F, Zou W, Zhang DE (2007). "ISG15 modification of the eIF4E cognate 4EHP enhances cap structure-binding activity of 4EHP". Genes Dev. 21 (3): 255–60. DOI:10.1101/gad.1521607. PMC 1785121. PMID 17289916. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1785121.
Ewing RM, Chu P, Elisma F et al. (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. DOI:10.1038/msb4100134. PMC 1847948. PMID 17353931. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1847948.
Rosettani P, Knapp S, Vismara MG et al. (2007). "Structures of the human eIF4E homologous protein, h4EHP, in its m7GTP-bound and unliganded forms". J. Mol. Biol. 368 (3): 691–705. DOI:10.1016/j.jmb.2007.02.019. PMID 17368478.
Zuberek J, Kubacka D, Jablonowska A et al. (2007). "Weak binding affinity of human 4EHP for mRNA cap analogs". RNA 13 (5): 691–7. DOI:10.1261/rna.453107. PMC 1852817. PMID 17369309. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1852817.

PDB gallery

2jgb: STRUCTURE OF HUMAN EIF4E HOMOLOGOUS PROTEIN 4EHP WITH M7GTP

2jgc: STRUCTURE OF THE HUMAN EIF4E HOMOLOGOUS PROTEIN, 4EHP WITHOUT LIGAND BOUND

Protein biosynthesis: translation (prokaryotic, eukaryotic)

Ribosomal proteins

Initiation factor

Prokaryotic	PIF-1 · PIF-2 · PIF-3

Archaeal	aIF1 · aIF2 · aIF5 · aIF6

Eukaryotic	eIF1 (EIF1AX, AY, 1B) eIF2 (EIF2S1, EIF2S2, EIF2S3) · EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5 · EIF-2 kinase eIF3 (EIF3A, B, C, D, F, G, H, I, J, K, M, S6) eIF4 (EIF4A2, A3, B, E1, E2, G1, G2, G3, H) eIF5 (EIF5A, A2, B) eIF6 (EIF6)

Elongation factor

Prokaryotic	EF-Tu, EF-Ts, EF-G

Archaeal	aEF-1, aEF-2

Eukaryotic	EEF-1 (EEF1A1, EEF1A2, EEF1A3, EEF1B1, EEF1B2, EEF1B3, EEF1B4, EEF1D, EEF1E1, EEF1G) · EEF2

Release factor

Prokaryotic · Archaeal · Eukaryotic (ETF1)

Other

RPS1 · RPS2 · RPS3 · RPS4 · RPS5 · RPS6 · RPS7 · RPS8 · RPS9 · RPS10 · RPS11 · RPS12 · RPS13 · RPS14 · RPS15 · RPS16 · RPS17 · RPS18 · RPS19 · RPS20 · RPS21 · RPS22 · RPS23 · RPS24 · RPS25 · RPS26 · RPS27 · RPS28 · RPS29

Other concepts

Aminoacyl tRNA synthetase · Reading frame · Start codon · Stop codon · Shine-Dalgarno sequence/Kozak consensus sequence

see also disorders of translation and posttranslational modification
B bsyn: dna (repl, cycl, reco, repr) · tscr (fact, tcrg, nucl, rnat, rept, ptts) · tltn (risu, pttl, nexn) · dnab, rnab/runp · stru (domn, 1°, 2°, 3°, 4°)

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Interactions [link]

References [link]

Further reading [link]

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