EHMT2
Euchromatic histone-lysine N-methyltransferase 2 (EHMT2), also known as G9a, is a histone methyltransferase that in humans is encoded by the EHMT2 gene.
Function
A cluster of genes, BAT1-BAT5, has been localized in the vicinity of the genes for TNF alpha and TNF beta. This gene is found near this cluster; it was mapped near the gene for C2 within a 120-kb region that included a HSP70 gene pair. These genes are all within the human major histocompatibility complex class III region. This gene was thought to be two different genes, NG36 and G9a, adjacent to each other but a recent publication shows that there is only a single gene. The protein encoded by this gene is thought to be involved in intracellular protein-protein interaction. There are three alternatively spliced transcript variants of this gene but only two are fully described.
G9a and G9a-like protein, another histone-lysine N-methyltransferase, catalyze the dimethylated state of H3K9me2. G9a is an important control mechanism of the epigenetic regulation in addiction that occurs in the nucleus accumbens, as it opposes the induction of ΔFosB expression and is suppressed by ΔFosB. G9a exerts opposite effects to that of ΔFosB on drug-related behavior (e.g., self-administration) and synaptic remodeling (e.g., dendritic arborization) in the nucleus accumbens, and therefore opposes ΔFosB's function as well as increases in its expression.
Podcasts:
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by Linkin Park
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by Fabolous
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by Ghostface Killah
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by Busta Rhymes
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by Umberto Tozzi
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by ToTo
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by John P. Kee
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by Hezekiah Walker
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by Catherine Corelli
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by New Life Community Choir
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by Teddy Thompson
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by Juice
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by Dj Shadow
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by Madita
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by Jeremy Spencer
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by Overdust
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by Ray Smith
We Made It
by: Linkin Park[Chester Bennington]
Together we made it
We made it even though we had our backs up against the wall
[Busta Rhymes:]
See ah niggas i survived the worst but my life is glorious
Betta know that i leaped every hurdle and i'm so victorious
Take a look, I'm a symbol of greatness now call a nigga Morpheus
As force securing the win and I believe I'm so notorious
You know that I've been buying my bread even though we rapping now (yes)
We use to live on the strip and you see a nigga higher level tramping now
Superceded everyone of my middle struggles and
Failure never ever has been an option
A nigga paper long like we was on the trap and we bout ta take the hood shoppin'
Get it!
[Chorus: Chester Bennington] (Busta Rhymes) *Mike Shinoda*
Together we made it (you see we did it niggas)
We made it even though we had our backs up against the wall (c'mon)
Forever we waited (haha!)
And they told us we were never going to get it
but we took it on the road (to the riches)
on the road (to the ghetto)
on the roooooad (in the projects to this bangin instrumental)
on the road (ride with me) *yeah, yeah*
on the road (you come and get it) *yeah, yeah*
on the roooooooad *yeah, yeah, yeah, yo!*
[Mike Shinoda:]
When it all got started we was steadily just getting rejected
And it seemed like nothing we could do would ever get us respected
At best we were stressed and the worst they probably said we're pathetic
Had all the pieces to that puzzle just no way to connect it
And I was fighting through every rhyme tightening up every line
Never resting the question if I was out of my mind
And it finally came time to do it or let it die
So put the chips on the table and told 'em to let it ride
Sing it!
[Chorus: Chester Bennington] (Busta Rhymes)
Together we made it (you see we did it niggas)
We made it even though we had our backs up against the wall (c'mon)
Forever we waited (haha!)
And they told us we were never going to get it
but we took it on the road (to the riches)
on the road (to the ghetto)
on the roooooad (in the projects to this bangin instrumental)
on the road (ride with me)
on the road (you come and get it)
on the roooooooad
[Busta Rhymes:]
Look in case you misunderstand exactly what I'm building
Shit that I could leave for my children (children) children (children)
Now I only wake up with a smile to see how far I've come
Fighting for sales on a strip to get the hustle from
From nights in jail on a bench using my muscles son
To counting money like Dre and Jimmy or Russell One
But now I live what I dream you see we finally did it
Let's make a toast to the hustle regardless how you did it
Sing it
[Chorus: Chester Bennington] (Busta Rhymes)
Together we made it (you see we did it niggas)
We made it even though we had our backs up against the wall (c'mon)
Forever we waited (haha!)
And they told us we were never going to get it
but we took it on the road (to the riches)
on the road (to the ghetto)
on the roooooad (in the projects to this bangin instrumental)
on the road (ride with me)
on the road (you come and get it)