Echs1

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Enoyl CoA hydratase, short chain, 1, mitochondrial

PDB rendering based on 1dub.

Available structures

PDB

Ortholog search: PDBe, RCSB

List of PDB id codes
2HW5

Identifiers

Symbols

ECHS1; SCEH

External IDs

OMIM: 602292 MGI: 2136460 HomoloGene: 3018 GeneCards: ECHS1 Gene

EC number

4.2.1.17

Gene Ontology
Molecular function	• enoyl-CoA hydratase activity • protein binding • lyase activity
Cellular component	• soluble fraction • mitochondrion • mitochondrion • mitochondrial matrix
Biological process	• fatty acid metabolic process • fatty acid beta-oxidation • cellular lipid metabolic process • small molecule metabolic process
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 10:
135.18 – 135.19 Mb

Chr 7:
147.29 – 147.3 Mb

PubMed search

[1]

[2]

Enoyl Coenzyme A hydratase, short chain, 1, mitochondrial, also known as ECHS1, is a human gene.^[1]

The protein encoded by this gene functions in the second step of the mitochondrial fatty acid beta-oxidation pathway. It catalyzes the hydration of 2-trans-enoyl-coenzyme A (CoA) intermediates to L-3-hydroxyacyl-CoAs. The gene product is a member of the hydratase/isomerase superfamily. It localizes to the mitochondrial matrix. Transcript variants utilizing alternative transcription initiation sites have been described in the literature.^[1]

References [link]

^ ^a ^b "Entrez Gene: ECHS1 enoyl Coenzyme A hydratase, short chain, 1, mitochondrial". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1892.

Further reading [link]

Hochstrasser DF, Frutiger S, Paquet N, et al. (1993). "Human liver protein map: a reference database established by microsequencing and gel comparison.". Electrophoresis 13 (12): 992–1001. DOI:10.1002/elps.11501301201. PMID 1286669.
Dawson SJ, White LA (1992). "Treatment of Haemophilus aphrophilus endocarditis with ciprofloxacin.". J. Infect. 24 (3): 317–20. DOI:10.1016/S0163-4453(05)80037-4. PMID 1602151.
Li J, Norwood DL, Mao LF, Schulz H (1991). "Mitochondrial metabolism of valproic acid.". Biochemistry 30 (2): 388–94. DOI:10.1021/bi00216a012. PMID 1988037.
Jackson S, Schaefer J, Middleton B, Turnbull DM (1995). "Characterisation of a novel enzyme of human fatty acid beta-oxidation: a matrix-associated, mitochondrial 2-enoyl-CoA hydratase.". Biochem. Biophys. Res. Commun. 214 (1): 247–53. DOI:10.1006/bbrc.1995.2281. PMID 7669045.
Kanazawa M, Ohtake A, Abe H, et al. (1994). "Molecular cloning and sequence analysis of the cDNA for human mitochondrial short-chain enoyl-CoA hydratase.". Enzyme Protein 47 (1): 9–13. PMID 8012501.
Janssen U, Davis EM, Le Beau MM, Stoffel W (1997). "Human mitochondrial enoyl-CoA hydratase gene (ECHS1): structural organization and assignment to chromosome 10q26.2-q26.3.". Genomics 40 (3): 470–5. DOI:10.1006/geno.1996.4597. PMID 9073515.
Hubbard MJ, McHugh NJ (2001). "Human ERp29: isolation, primary structural characterisation and two-dimensional gel mapping.". Electrophoresis 21 (17): 3785–96. DOI:10.1002/1522-2683(200011)21:17<3785::AID-ELPS3785>3.0.CO;2-2. PMID 11271497.
Jiang LQ, Wen SJ, Wang HY, Chen LY (2003). "Screening the proteins that interact with calpain in a human heart cDNA library using a yeast two-hybrid system.". Hypertens. Res. 25 (4): 647–52. DOI:10.1291/hypres.25.647. PMID 12358155.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10.". Nature 429 (6990): 375–81. DOI:10.1038/nature02462. PMID 15164054.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. DOI:10.1101/gr.2596504. PMC 528928. PMID 15489334. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
Bruneel A, Labas V, Mailloux A, et al. (2006). "Proteomics of human umbilical vein endothelial cells applied to etoposide-induced apoptosis.". Proteomics 5 (15): 3876–84. DOI:10.1002/pmic.200401239. PMID 16130169.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3 (1): 89. DOI:10.1038/msb4100134. PMC 1847948. PMID 17353931. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1847948.
Takahashi M, Watari E, Shinya E, et al. (2007). "Suppression of virus replication via down-modulation of mitochondrial short chain enoyl-CoA hydratase in human glioblastoma cells.". Antiviral Res. 75 (2): 152–8. DOI:10.1016/j.antiviral.2007.02.002. PMID 17395278.