Sony Cyber-shot DSC-R1

The Sony Cyber-shot DSC-R1 is a bridge digital camera announced by Sony in 2005 (and discontinued in 2006). It featured a 10.3 megapixel APS-C CMOS sensor (21.5 × 14.4 mm), a size typically used in DSLRs and rarely used in bridge cameras (which usually use 2/3" (= 6.6 × 8.8 mm) or 1/1.8" (= 5.3 × 7.1 mm)). This was the first time such a large sensor was incorporated into a bridge camera. Besides the APS-C sensor, the DSC-R1 also featured a 14.3–71.5 mm Carl Zeiss Vario-Sonnar T* lens, providing for an angle of view equivalent to 24–120 mm on a full frame camera.

Advantages

Compared to a standard DSLR the Sony DSC-R1 had the following advantages:

DSC

DSC is an initialism or abbreviation used in many fields:

Academia

Science and technology

DSC3

Desmocollin-3 is a protein that in humans is encoded by the DSC3 gene.

Gene

The desmosomal family members are arranged in two clusters on chromosome 18, occupying less than 650 kb combined. Alternative splicing results in two transcript variants encoding distinct isoforms.

Function

Desmocollin-3 is a calcium-dependent glycoprotein that is a member of the desmocollin subfamily of the cadherin superfamily. These desmosomal family members, along with the desmogleins, are found primarily in epithelial cells where they constitute the adhesive proteins of the desmosome cell-cell junction and are required for cell adhesion and desmosome formation. The loss of these components leads to a lack of adhesion and a gain of cellular mobility.

Clinical significance

Breast cancer

Through the process of epigenetic silencing, the expression of the desmocollin 3 protein is down regulated in many breast cancers.

Hereditary hypotrichosis

DSC1

Desmocollin-1 is a protein that in humans is encoded by the DSC1 gene.

The protein encoded by this gene is a calcium-dependent glycoprotein that is a member of the desmocollin subfamily of the cadherin superfamily. These desmosomal family members, along with the desmogleins, are found primarily in epithelial cells where they constitute the adhesive proteins of the desmosome cell-cell junction and are required for cell adhesion and desmosome formation. The desmosomal family members are arranged in two clusters on chromosome 18, occupying less than 650 kb combined. Alternative splicing results in two transcript variants encoding distinct isoforms.

Interactions

DSC1 has been shown to interact with Desmoglein 2.

References

Further reading