Drop (unit)

The drop is a unit of measure of volume, the amount dispensed as one drop from a dropper or drip chamber. It is often used in giving quantities of liquid drugs to patients, and occasionally in cooking.

The volume of a drop is not well-defined: it depends on the device and technique used to produce the drop, on the strength of the gravitational field, and on the density and the surface tension of the liquid.

There are several exact definitions of a "drop":

Drop (music)

A drop in popular music, especially electronic music styles, is a point in a music track where a switch of rhythm or bass line occurs and usually follows a recognizable build section and break.

The term "drop" comes from the composer or producer "dropping in" the primary rhythmic and foundational elements previously hinted at into the mix more or less at once. Related terms, typically describing certain types of drops, include "beat-up" (so named because it is a point where the producer brings up the foundational kick drum beat after having faded it down during a break or buildup) and "climax" (typically describing a single particularly striking drop heard late in the track).

Types

Many genres of EDM can have more than one drop during a track, especially if the song is built on a "dance-pop" verse/chorus with vocals; a drop of some kind is typically heard somewhere during each chorus as the high point of that verse/chorus cycle. Most genres, however, tend to emphasize a single drop as the beginning of the high point, or climax, of the entire track; in vocal subgenres this is typically the last repetition of the chorus, while in nonvocal genres it typically occurs in the last quarter of the track.

Overhand (boxing)

An overhand (or overcut or drop) is a semi-circular and vertical punch thrown with the rear hand. It is usually employed when the opponent is bobbing or slipping. The strategic utility of the drop relying on body weight can deliver a great deal of power.

Left overhand in long range

Left overhand in long range

Right overhand in long range

Right overhand in long range

Left overhand in long range and counterpunch

Left overhand in long range and counterpunch

External links

Movies

Birth Through Knowledge

Birth Through Knowledge (aka BTK) was a Canadian hip-hop/rock band best known for their 1998 single "Peppyrock," the video for which was nominated for the 1998 MuchMusic Best Video Award. The band consisted of Lo-Ki (vocals), Stone Groove (vocals), DJ Spinz (turntables), Adam Carlo (bass),Sam Cino (drums,percussion) and Matt deMatteo (drums).

After signing onto the Tommyboy/Ignition label, BTK released one album "Birth Thru Knowledge" in 1998.

BTK first came to attention when their song "Corncob Pipe" was included on the sampler disc that Korn released alongside Follow the Leader. They were the first indie band to ever open the main-stage at Edgefest '97. In 1998, the band toured with the Beastie Boys and with Our Lady Peace. They appeared in the 1998 Summersault tour.

The band won the 1997 MuchMusic Best Independent Video Award for "Superchile." They were also nominated for a Juno Award in 1999 in the Best Alternative Album category, losing to Rufus Wainwright.

Footnotes

Bruton's tyrosine kinase

Bruton's tyrosine kinase (abbreviated Btk or BTK) also known as tyrosine-protein kinase BTK is an enzyme that in humans is encoded by the BTK gene. BTK is a kinase that plays a crucial role in B-cell development.

Function

BTK plays a crucial role in B cell maturation as well as mast cell activation through the high-affinity IgE receptor.

Btk contains a PH domain that binds phosphatidylinositol (3,4,5)-trisphosphate (PIP3). PIP3 binding induces Btk to phosphorylate phospholipase C, which in turn hydrolyzes PIP₂, a phosphatidylinositol, into two second messengers, inositol triphosphate (IP3) and diacylglycerol (DAG), which then go on to modulate the activity of downstream proteins during B-cell signalling.

Clinical significance

Mutations in the BTK gene are implicated in the primary immunodeficiency disease X-linked agammaglobulinemia (Bruton's agammaglobulinemia). Patients with XLA have normal pre-B cell populations in their bone marrow but these cells fail to mature and enter the circulation. The Btk gene is located on the X chromosome. At least 400 mutations of the BTK gene have been identified.