Dopexamine

Dopexamine is a synthetic analogue of dopamine. Despite this, it is a β₁ and β₂-adrenergic receptor agonist. Its action at dopamine receptor D1 mediates relaxation of vascular smooth muscle in renal, mesenteric, cerebral and coronary arteries. Mild action at D2 receptors decreases noradrenaline release.

Use in sepsis has been proposed.

It is used as an inotropic agent in cardiac failure. Side effects include arrhythmia, tremor, angina and flushing.

Synthesis

Condensation of the adipic acid derivative 1 with phenethylamine in the presence of Carbonyldiimidazole affords bis-adipic acid amide 2. The synthesis is completed by reduction of the carbonyl groups with diborane followed by demethylation of the aromatic methoxy groups with hydrogen bromide to afford dopexamine.

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