A domino is a tile used in the game dominoes.
Domino may also refer to:
- Domino (Squeeze album), 1998
- Domino (Domino album), 1993
- Domino (Rahsaan Roland Kirk album), 1962
- "Domino" (Genesis song), 1986
- "Domino" (Van Morrison song), 1970
- "Domino" (1950 song), a song by Louis Ferrari and Jacques Plante and Don Raye, popularized by Bing Crosby among others
- "Domino" (Kiss song), 1992
- "Dominos" (The Big Pink song), 2009
- "Domino" (Jessie J song), 2011
- "Dominoes", a song by Syd Barrett from his 1970 album Barrett
- "Dominoes", a song by Robbie Nevil from his 1986 self-titled debut album
- Domino Recording Company, known as Domino, based in London
- Domino Records (before 1993), the name of several United States record labels which are now defunct
- Derek and the Dominos, a band from the early seventies with Eric Clapton as a member
- Billy Ward and the Dominoes, a vocal group that included Clyde McPhatter and Jackie Wilson
- Anna Domino, folk singer-songwriter
- Domino (band), band, formed around lead vocalist Domino Kirke
- Domino (producer) (born 1970), producer and member of the band Hieroglyphics
- Domino (rapper) (born 1972), rapper
- Domino Harvey (1969–2005), bounty hunter, model, and daughter of actor Laurence Harvey
- Domino Vitali, character in the James Bond novel Thunderball
- Fats Domino (born 1928), R&B singer and songwriter
- Stage name of Cliff Compton, professional wrestler
- Former stage name of Sofia Coppola, film director and actor
- Domino (2005 film), a 2005 film starring Keira Knightley based on the life of Domino Harvey
- Domino (1988 film), a 1988 Italian film starring Brigitte Nielsen
- Domino (magazine), a magazine focused on shopping for the home
- Domino (comics), a Marvel Comics character in X-Force
- Domino (horse), American thoroughbred race horse
- Domino (car), a range of Mini-based kit cars
- Domino (mathematics), the polyomino of order two
- Domino logic, a logic technique used in many modern integrated circuits
- Domino jointer, a jointing machine invented by Festool Gmbh
- Daihatsu Domino, European name for the Daihatsu Mira car
- Dominos (arcade game), a 1977 arcade game by Atari
- Dominoes, a collection of stories by Bali Rai
- Domino's Pizza, an international pizza restaurant chain
- Domino Foods, Inc., sugar refining company founded by Henry Osborne Havemeyer
- Domino Printing Sciences, British-based developer of ink jet and laser printing solutions
- IBM Lotus Domino, the server element to the Lotus Notes client-server package
- Domino or Threespot dascyllus, a marine fish
- Domino 55, Domino 67, or Domino 69, series of railway signal boxes developed by Integra Signum
- Benedicamus Domino, a closing salutation used in the Roman Mass
- Domino, a vehicle which is part of Team Knight Rider (voiced by Nia Vardalos)