Chaperone DnaJ
In molecular biology, chaperone DnaJ, also known as Hsp40 (heat shock protein 40 kD), is a molecular chaperone protein. It is expressed in a wide variety of organisms from bacteria to humans.
Function
Molecular chaperones are a diverse family of proteins that function to protect proteins from irreversible aggregation during synthesis and in times of cellular stress. The bacterial molecular chaperone DnaK is an enzyme that couples cycles of ATP binding, hydrolysis, and ADP release by an N-terminal ATP-hydrolizing domain to cycles of sequestration and release of unfolded proteins by a C-terminal substrate binding domain. Dimeric GrpE is the co-chaperone for DnaK, and acts as a nucleotide exchange factor, stimulating the rate of ADP release 5000-fold. DnaK is itself a weak ATPase; ATP hydrolysis by DnaK is stimulated by its interaction with another co-chaperone, DnaJ. Thus the co-chaperones DnaJ and GrpE are capable of tightly regulating the nucleotide-bound and substrate-bound state of DnaK in ways that are necessary for the normal housekeeping functions and stress-related functions of the DnaK molecular chaperone cycle.
Podcasts:
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by Donnie J
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You Make Me Feel
by: Donnie J[Verse 1:]
I can't explain
Don't understand but everyday I think about you
Your the one and it's for real
There ain't no words it's just how I feel
Deep down inside and I can't hide the way you make me feel so high
[Chorus:]
And I cannot deny
You make me feel...
Like a kid in a candy store
You make feel...
Like I've never been here before
You make me feel...
Everyday is my birthday
You makin' feel this way
You make me feel...
Like I just won the lottery
You make me feel...
Like I'm chanin' my ensame
And I thought about
Never thought I'd feel this way
You make me feel
[Hook:]
I'm gunna come get you I can't get you outta my mind
I'm gunna come get you girl I gotta make you more mine
[Verse 2:]
I get butterflys everytime
I stare deep into those eyes
Maybe I'm helpless or I'm just selfish
Cause I want you all too myself
Oooh what I'll give to make you mine
There's nothing that I would not try
And that's the reason why
You make me feel...
[Chorus:]
Like a kid in a candy store
You make feel...
Like I've never been here before
You make me feel...
Everyday is my birthday
You makin' feel this way
You make me feel...
Like I just won the lottery
You make me feel...
Like I'm chanin' my ensame
And I thought about
Never thought I'd feel this way
You make me feel
[Verse 3:]
I'm gunna come get you I can't get you outta my mind
I can't help my hearts like and open book
Won't you take a look
Cause' it ain't hard to see that you got me
OH NA
Baby... the way you got me feelin' is kinda
Crazy... what you got is what I need
I'm lovin' everything I see
We fit perfectly
Cause...
[Chorus:]
You make me feel...
Like a kid in a candy (ohh)
You make me feel...
Like I've never been here before (mmm)
Everyday is my birthday
Everyday is my bithday (yeah) feel this way
I said you make me feel...
Like I just won the lottery (oh like I just won the lottery)
Like I'm changin my ensame
And... I thought about never thought I'd feel this way