DLX6-AS1
DLX6 antisense RNA 1 (DLX6-AS1) (Evf-1 (Embryonic ventral forebrain-1)) is a developmentally-regulated long non-coding RNA. In rats, it is expressed in neurons in the subventricular zone of the developing forebrain. Its expression is linked to that of the Shh (sonic hedgehog) and DLX families of genes, which are important in ventral forebrain and craniofacial development. An alternatively spliced form of DLX6-AS1, DLX6-AS2, forms a stable complex with the Dlx-2 protein. This complex activates transcription of Dlx-5 and Dlx-6.
DLX6-AS2 regulates gene expression in a region of the brain which produces GABAergic interneurons during development. It is involved in the signaling pathway and works in conjunction with DLX homeodomain proteins to increase the effectiveness of the Dlx5/6 enhancer element within neural stem cells. The interneurons are found in the hippocampus of the adult brain, an area responsible for learning and memory.
GABAergic interneurons have been implicated in a number of psychiatric disorders including autism,schizophrenia and epilepsy; as DLX6-AS2 controls the development of these neurones, it has been subject to studies regarding the causation of these disorders.
DLX6
Homeobox protein DLX-6 is a protein that in humans is encoded by the DLX6 gene.
This gene encodes a member of a homeobox transcription factor gene family similar to the Drosophila distal-less gene. This family has at least six members that encode proteins with roles in forebrain and craniofacial development. This gene is in a tail-to-tail configuration with another member of the family on the long arm of chromosome 7.
References
Further reading
AS1
AS1 or AS-1 may refer to:
- The AS-1 was a Soviet-era prototype assault rifle that led to the AN-94.
- A prototype bullpup AK-12 created by the Kalashnikov Concern in 2013, as part of the development of a rifle for the FSB, and possibly as part of the Ratnik modernization program of the Russian Army. The AS ("Автомат Специальный" Avtomat Spetsial'nyy, "Special automatic [rifle]") has two models, the AS-1 in 5.45×39mm and the AS-2 in 7.62×39mm.
AS1 (networking)
AS1 (Applicability Statement 1) is a specification about how to transport data securely and reliably over the Internet. Security is achieved by using digital certificates and encryption.
AS1 Technical Overview
The AS1 protocol is based on SMTP and S/MIME. It was the first AS protocol developed and uses signing, encryption and MDN conventions. In other words:
- Upon the receipt of the message and its successful decryption or signature validation (as necessary) a "success" MDN will be sent back to the original sender. This MDN is typically signed but not encrypted.
- Upon the receipt and successful verification of the signature on the MDN, the original sender will "know" that the recipient got their message (this provides the "Non-repudiation" element of AS1)
- If there are any problems receiving or interpreting the original AS1 message, a "failed" MDN may be sent back.
Podcasts:
