Diana!

Diana! is American singer Diana Ross' first solo TV special, which aired on ABC on April 18, 1971, choreographed by David Winters of West Side Story fame, who at that time choreographed all of Ross' stage and TV shows. The special featured performances by The Jackson 5, and also included Jackson 5 lead singer Michael Jackson's solo debut. Michael Jackson performed Frank Sinatra's "It Was a Very Good Year", which drew laughter as its adult-themed lyrics were changed to fit his age. Other guests included Danny Thomas and Bill Cosby, who would be featured on a similar TV special by the Jackson 5 (Goin' Back to Indiana) a few months later.

Since this was right at the beginning of her solo career, she took the opportunity to promote the two hits from her debut, the gold audience participant "Reach Out and Touch (Somebody's Hand)" and the number 1 song "Ain't No Mountain High Enough". She also performed a cover of The Carpenters "(They Long to Be) Close to You" and the top-20 gold single "Remember Me" released that previous December 1970 included on her forthcoming album "Surrender" to be released later that summer. (Though she performed "Reach Out and Touch (Somebody's Hand)" on the special, it was not included on the soundtrack).

Diana (Saint-Gaudens)

Diana – also known as Diana of the Tower – is an iconic statue by sculptor Augustus Saint-Gaudens. Once a famous New York City landmark, the second version stood atop the tower of Madison Square Garden from 1893 to 1925. Since 1932, it has been in the collection of the Philadelphia Museum of Art.

First Version (1891-1892)

"Diana" was commissioned by architect Stanford White as a weathervane for the tower of Madison Square Garden, a theater-and-dining complex at 26th Street and Madison Avenue in Manhattan. He talked his friend Saint-Gaudens into creating it at no charge, and picked up the cost of materials. Model Julia "Dudie" Baird posed for the body of the statue. Its face is that of Davida Johnson Clark, Saint-Gauden's long-time model and mother of his illegitimate son Louis.

The first version – built by the W. H. Mullins Manufacturing Company in Salem, Ohio – was 18 ft (5.5 m) tall and weighed 1,800 lb (820 kg). Saint-Gaudens's design specified that the figure appear to delicately balance on its left toe atop a ball. However, the Ohio metal shop was unable to pass the rotating rod through the toe, so the design was altered and the figure instead was poised (less-gracefully) on its heel.

Diana (given name)

Diana or Diane is a feminine given name probably derived from an Indo-European root word referring to the divine. It is the name of the Roman goddess Diana, the goddess of the hunt, forests, and childbirth. The French form of the name is Diane. In Persian language Diana means "supplier (messenger) of beneficence & wellness". Diana has consistently ranked among the top 200 names used for girls born in the United States since the 1930s. It was the 107th most popular name for baby girls born in the United States in 2007. It was the 96th most common name for girls and women in the United States in the 1990 census. Diana ranks among the 100 most popular names for baby girls born in Hungary, Spain, and Ukraine, where it was among the top 10 most popular names for baby girls born in 2008.

It may refer to:

People with the given name Diana

Nuclear receptor coactivator 2

The nuclear receptor coactivator 2 also known as NCoA-2 is a protein that in humans is encoded by the NCOA2 gene. NCoA-2 is also frequently called glucocorticoid receptor-interacting protein 1 (GRIP1), steroid receptor coactivator-2 (SRC-2), or transcriptional mediators/intermediary factor 2 (TIF2).

Function

NCoA-2 is a transcriptional coregulatory protein that contains several nuclear receptor interacting domains and an intrinsic histone acetyltransferase activity. NCOA2 is recruited to DNA promotion sites by ligand-activated nuclear receptors. NCOA2 in turn acetylates histones, which makes downstream DNA more accessible to transcription. Hence, NCOA2 assists nuclear receptors in the upregulation of DNA expression.

GRIP1 is a transcriptional co-activator of the glucocorticoid receptor and interferon regulatory factor 1 (IRF1).

Interactions

Nuclear receptor coactivator 2 has been shown to interact with:

Nuclear receptor coactivator 3

The nuclear receptor coactivator 3 also known as NCOA3 is a protein that, in humans, is encoded by the NCOA3 gene. NCOA3 is also frequently called 'amplified in breast 1' (AIB1), steroid receptor coactivator-3 (SRC-3), or thyroid hormone receptor activator molecule 1 (TRAM-1).

Function

NCOA3 is a transcriptional coactivator protein that contains several nuclear receptor interacting domains and an intrinsic histone acetyltransferase activity. NCOA3 is recruited to DNA promotion sites by ligand-activated nuclear receptors. NCOA3, in turn, acylates histones, which makes downstream DNA more accessible to transcription. Hence, NCOA3 assists nuclear receptors in the upregulation of gene expression.

Clinical significance

The ratio of PAX2 to AIB-1 protein expression may be predictive of the effectiveness of tamoxifen in breast cancer treatment.

Interactions

Nuclear receptor coactivator 3 has been shown to interact with:

Nuclear receptor coactivator 1

The nuclear receptor coactivator 1 (NCOA1) is a transcriptional coregulatory protein that contains several nuclear receptor interacting domains and an intrinsic histone acetyltransferase activity (EC 2.3.1.48). NCOA1 is recruited to DNA promotion sites by ligand-activated nuclear receptors. NCOA1, in turn, acylates histones, which makes downsteam DNA more accessible to transcription. Hence, NCOA1 assists nuclear receptors in the upregulation of DNA expression.

NCOA1 is also frequently called steroid receptor coactivator-1 (SRC-1).

Interactions

Nuclear receptor coactivator 1 possesses a basic helix-loop-helix (bHLH) domain and has been shown to interact with:

References

External links