Desiree
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Désirée (film)
Désirée is a 1954 historical film biography made by 20th Century Fox. It was directed by Henry Koster and produced by Julian Blaustein from a screenplay by Daniel Taradash, based on the best-selling novel Désirée by Annemarie Selinko. The music score was by Alex North and the cinematography by Milton R. Krasner. The film was made in CinemaScope.
It stars Marlon Brando, Jean Simmons, Merle Oberon and Michael Rennie with Cameron Mitchell, Elizabeth Sellars, Charlotte Austin, Cathleen Nesbitt, Carolyn Jones and Evelyn Varden.
The film was nominated for two Academy Awards, for Best Art Direction (Lyle Wheeler, Leland Fuller, Walter M. Scott, Paul S. Fox) and Costume Design (Rene Hubert and Charles LeMaire).
Plot
In 1794, in Marseille, Désirée Clary (Jean Simmons) makes the acquaintance of a Corsican named Joseph Bonaparte (Cameron Mitchell) and invites him and his brother, General Napoleon Bonaparte (Marlon Brando), to call upon the family the following day. The next day, Julie (Elizabeth Sellars), Désirée's sister and Joseph are immediately attracted to each other, and Napoleon is taken with Désirée. He admits to her that the poor Bonaparte brothers need the rich dowries of the Clary sisters. Later, Désirée learns that Napoleon has been arrested and taken to Paris.
Desiree (song)
"Desiree" is a 1977 song written and recorded by Neil Diamond and included as a track on Diamond's 1977 album, I'm Glad You're Here with Me Tonight. The single peaked at number sixteen on the Billboard Hot 100 and reached number one on the Easy Listening chart to become his fifth number one on that chart.
It was used as the first long-distance dedication on American Top 40 on the show aired August 26, 1978.
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Drip
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DRIP
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MED1
Mediator of RNA polymerase II transcription subunit 1 also known as DRIP205 or Trap220 is a subunit of the Mediator complex and is a protein that in humans is encoded by the MED1 gene. MED1 functions as a nuclear receptor coactivator.
Function
The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The mediator of RNA polymerase II transcription subunit 1 protein is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes [e.g., thyroid hormone receptor-(TR-) associated proteins that interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors]. It also regulates p53-dependent apoptosis and it is essential for adipogenesis. This protein is known to have the ability to self-oligomerize.
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