Fatty acid desaturase
A fatty acid desaturase is an enzyme that removes two hydrogen atoms from a fatty acid, creating a carbon/carbon double bond. These desaturases are classified as
In the biosynthesis of essential fatty acids, an elongase alternates with different desaturases (for example, Δ6desaturase) repeatedly inserting an ethyl group, then forming a double bond.
Role in human metabolism
Four desaturases occur in humans: Δ9desaturase, Δ6desaturase, Δ5 desaturase, and Δ4 desaturase.
Δ9desaturase, also known as stearoyl-CoA desaturase-1, is used to synthesize oleic acid, a monounsaturated, ubiquitous component of all cells in the human body. Δ9desaturase produces oleic acid by desaturating stearic acid, a saturated fatty acid either synthesized in the body from palmitic acid or ingested directly.
Stearoyl-CoA desaturase-1
Stearoyl-CoA desaturase (delta-9-desaturase) is a protein that in humans is encoded by the SCD gene.
Stearoyl-CoA desaturase-1 is a key enzyme in fatty acid metabolism. It is responsible for forming a double bond in Stearoyl-CoA. This is how the monounsaturated fatty acid oleic acid is produced from the saturated fatty acid stearic acid.
Function
Stearoyl-CoA desaturase (SCD; EC 1.14.19.1) is an iron-containing enzyme that catalyzes a rate-limiting step in the synthesis of unsaturated fatty acids. The principal product of SCD is oleic acid, which is formed by desaturation of stearic acid. The ratio of stearic acid to oleic acid has been implicated in the regulation of cell growth and differentiation through effects on cell membrane fluidity and signal transduction. Four SCD isoforms, Scd1 through Scd4, have been identified in mouse. In contrast, only 2 SCD isoforms, SCD1 and SCD5 (MIM 608370), have been identified in human. SCD1 shares about 85% amino acid identity with all 4 mouse SCD isoforms, as well as with rat Scd1 and Scd2. In contrast, SCD5 shares limited homology with the rodent SCDs and appears to be unique to primates.
Podcasts:
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by Dusty Roze
Spring Break Girl
by: Dusty RozeSPRING BREAK GIRL
CHORUS:
Wake and -- Wake and -- Wake and bake Spring Break
Wake and -- Wake and -- Wake and bake Spring Break
What do it take to make that ass shake?
BOY, BUY ME A DRINK OR PASS THE DANK
FIRST VERSE:
Back in the day/ Way up in Michigan
Was a little girl so good that it was sickenin'
Got straight "A"s/ Always went to church and
Never let nobody screw /she was a virgin
Talkin' bout: I'll wait til I get married
DON'T MASTURBATE/ YOUR PALMS'LL GET HAIRY
Then she went to college to get more knowledge
To get the money daddy refinanced the cottage
"Be a cheerleader, girl/ Don't be a slut"
OH, DAD -- YOU KNOW I'LL MAKE THE CUT
I'LL NEVER LET FRAT BOYS TOUCH MY BUTT
But oh shit -- when spring break came
The chick straight flipped -- turned insane
School let out -- she put a joint in her mouth
Headed for the sunshine somewhere south
Thong and bikini -- dudes checkin' her out
Repeat CHORUS
SECOND VERSE:
Panama City -- Fort Lauderdale
Causin' hell -- Getting' thrown in jail
Cancun South Beach -- Lake Havasu
Spring break girl I wanna fuck wit' you
DAD SAID NOT TO/ HE SAID BE CAUTIOUS
I DRANK TOO MUCH SO I'm FEELING NAUSEOUS
I DRANK TO MUCH SO I DRUNK PHONED YA
Gonna bone ya in Daytona
"Breaka breaka ten fo' -- spring break hoe
"Breaka breaka ten fo' -- spring break hoe
I'm NOT A HOE/ DON'T CALL ME THAT
JUST CAUSE YOU DID BODY SHOTS OFF MY BACK
WET T-SHIRT CONTESTS I'm THE BEST
TAKE MY CLOTHES OFF IN KEY WEST
Lookin' at yo' ass makes me start to think
HEY BOY! BUY ME A DRINK!
Repeat CHORUS
THIRD VERSE:
Partay in South Padre
Getting' ass Aspen
Jamaica Negril's got spring Break skills
Sorority priority
Hoppin' on a plane nickel bags in her breast
THEY WON'T SEARCH ME / I'm NOT A TERRORIST
Throwin' up in the alley bent over
If you're not sober/ she's your hair holder
Gettin' naughty/ Dance with everybody
Spring break girl at the foam party
SO MUCH FOAM I'm GETTING WET
BOOZE CRUISE /IS THERE A TOILET
If something's on the doorknob don't come in
Spring break girl's inside with a friend
BUMPING VOLLEYBALLS IN THE SAND