Benign fibrous histiocytomas (also known as "Dermal dendrocytoma,"[1] "Dermatofibroma,"[2] "Fibrous dermatofibroma,"[2] "Fibrous histiocytoma"[2]:668, "Fibroma simplex",[1] "Nodular subepidermal fibrosis",[1] and "Sclerosing hemangioma"[1]) are benign skin growths.[3]
Dermatofibromas are hard solitary slow-growing papules (rounded bumps) that may appear in a variety of colours, usually brownish to tan. In addition, they are often elevated or pedunculated. Although typical dermatofibromas cause little or no discomfort, itching and tenderness can occur. Some physicians and researchers believe dermatofibromas form as a reaction to previous injuries such as insect bites or thorn pricks.[4] They are composed of disordered collagen laid down by fibroblasts. In rare cases, basal cell carcinoma may develop in a dermatofibroma.
They are usually found on the leg.[5]
Deep penetrating dermatofibroma may be difficult to distinguish, even histologically, from rare malignant fibrohistocytic tumours like dermatofibrosarcoma protuberans.[6]
Dermatofibromas occur most often in women; the male to female ratio is about 1:4.[4] The age group in which the nodule occurs is twenty to forty-five years.
- ^ a b c d e Rapini, Ronald P.; Bolognia, Jean L.; Jorizzo, Joseph L. (2007). Dermatology: 2-Volume Set. St. Louis: Mosby. ISBN 1-4160-2999-0.
- ^ a b c Freedberg, et. al. (2003). Fitzpatrick's Dermatology in General Medicine. (6th ed.). McGraw-Hill. ISBN 0-07-138076-0.
- ^ "benign fibrous histiocytoma" at Dorland's Medical Dictionary
- ^ a b Pierson, Joseph C.; Diane M Pierson. "Dermatofibroma". eMedicine. WebMD. https://emedicine.medscape.com/article/1056742-overview. Retrieved 2009-06-13.
- ^ "dermatofibroma" at Dorland's Medical Dictionary
- ^ Hanly AJ, Jordà M, Elgart GW, Badiavas E, Nassiri M, Nadji M (June 2006). "High proliferative activity excludes dermatofibroma: report of the utility of MIB-1 in the differential diagnosis of selected fibrohistiocytic tumors". Archives of pathology & laboratory medicine 130 (6): 831–4. DOI:10.1043/1543-2165(2006)130[831:HPAEDR]2.0.CO;2. PMID 16740036. https://journals.allenpress.com/jrnlserv/?request=get-abstract&issn=0003-9985&volume=130&page=831.
- ^ Kim HJ, Lee JY, Kim SH, et al. (August 2007). "Stromelysin-3 expression in the differential diagnosis of dermatofibroma and dermatofibrosarcoma protuberans: comparison with factor XIIIa and CD34". Br. J. Dermatol. 157 (2): 319–24. DOI:10.1111/j.1365-2133.2007.08033.x. PMID 17596171.
- ^ https://emedicine.medscape.com/article/1056742-overview
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Diseases of the skin and appendages by morphology
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| Growths |
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| Rashes |
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With
epidermal
involvement
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Without
epidermal
involvement
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Red
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Generalized
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Localized
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Specialized
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Nonblanchable
Purpura
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Indurated
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Miscellaneous
disorders |
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| Dermis |
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Subcutaneous
tumors |
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Connective and
vascular
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Other
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