Chronopoulos was selected by the Ottawa Rough Riders with the third pick in the 1992 CFL Draft. He played in all 36 games during his tenure with the Rough Riders and was named a CFL East All-Star in 1993.
Chronopoulos signed with the Calgary Stampeders in March 1995. He was released by the Stampeders in 1996 after failing a physical due to a heart murmur.