Denis Noble

Denis Noble CBE FRS FRCP FMedSci (born 16 November 1936) is a British biologist who held the Burdon Sanderson Chair of Cardiovascular Physiology at the University of Oxford from 1984 to 2004 and was appointed Professor Emeritus and co-Director of Computational Physiology. He is one of the pioneers of Systems Biology and developed the first viable mathematical model of the working heart in 1960.

Education

Noble was educated at Emanuel School and University College London (UCL). In 1958 he began his investigations into the mechanisms of heartbeat. This led to two seminal papers in Nature in 1960 giving the first proper simulation of the heart. From this work it became clear that there was not a single oscillator which controlled heartbeat, but rather this was an emergent property of the feedback loops in the various channels. In 1961 he obtained his PhD working under the supervision of Otto Hutter at UCL.

Research

Noble's research focuses on using computer models of biological organs and organ systems to interpret function from the molecular level to the whole organism. Together with international collaborators, his team has used supercomputers to create the first virtual organ, the virtual heart.

Denis

According to Christian tradition, Saint Denis (also called Dionysius, Dennis, or Denys) is a Christian martyr and saint. In the third century, he was Bishop of Paris. He was martyred, with his companions Rusticus and Eleutherius, in connection with the Decian persecution of Christians, shortly after 250 AD. Denis is said to have picked his head up after being decapitated, walked ten kilometres (six miles), while preaching a sermon of repentance the entire way, making him one of many cephalophores in hagiology. He is venerated in the Roman Catholic Church as patron of Paris, France, and as one of the Fourteen Holy Helpers. The medieval and modern French name "Denis" derives from the ancient name Dionysius.

Life

Gregory of Tours states that Denis was bishop of the Parisii and was martyred by being beheaded by a sword. The earliest document giving an account of his life and martyrdom, the "Passio SS. Dionysii Rustici et Eleutherii" dates from c. 600, is mistakenly attributed to the poet Venantius Fortunatus, and is legendary. Nevertheless, it appears from the Passio that Denis was sent from Italy to convert Gaul in the third century, forging a link with the "apostles to the Gauls" reputed to have been sent out with six other missionary bishops under the direction of Pope Fabian. There Denis was appointed first Bishop of Paris. The persecutions under Emperor Decius had all but dissolved the small Christian community at Lutetia. Denis, with his inseparable companions Rusticus and Eleutherius, who were martyred with him, settled on the Île de la Cité in the River Seine. Roman Paris lay on the higher ground of the Left Bank, away from the river.

Denise (song)

"Denise" is a 1963 song by the American doo-wop group Randy & the Rainbows.

Original song information

Randy & the Rainbows worked with the producers of The Tokens, releasing the single "Denise" in 1963. The song spent seventeen weeks on the Billboard Hot 100, reaching no. 10, while reaching no. 18 on Billboard's Hot R&B Singles, and no. 5 on Canada's CHUM Hit Parade.

"Denise" was written by Neil Levenson, and was inspired by his childhood friend, Denise Lefrak.

Charts

Blondie version

"Denis" (pronounced De-nee) was a 1977 gender-swapping cover of the song by the American new wave band Blondie. The cover of the song helped the band break into the international market. It featured on the band's second studio album, Plastic Letters (1978), and was the second UK single release by Blondie on Chrysalis records.

The initial Blondie version contained a verse with partly improvised lyrics in French by the group's vocalist Debbie Harry. Although Chrysalis insisted that the band re-record the song with a grammatically correct French translation, both the band and producer Richard Gottehrer preferred the first take. Harry stood her ground on the matter, and the version containing the "pidgin French" lyrics was released. The second, re-recorded version had its debut as a bonus track on EMI UK's 1994 re-issue of Plastic Letters.

Denis (disambiguation)

Denis was the first Bishop of Paris.

Denis may also refer to:

People

Other uses

See also