The 309 road is a 22-kilometre (14 mi) long gravel road between the towns of Coromandel and Whitianga in New Zealand.
The 309 winds its way from Coromandel, on the west side of the Coromandel Peninsula, over the ranges to Whitianga, on the eastern side.
The road is considered extremely dangerous and deaths among tourists unfamiliar with the road and in unfit vehicles are common.
Places of interest along the road include Waiau Falls and the Kauri Grove, a stand of mature kauri trees.
Coordinates: 36°50′48″S 175°33′15″E / 36.846767°S 175.554208°E / -36.846767; 175.554208 (309 Road - nominal location)
The following highways are numbered 44.
The following highways are numbered 49:
Serum response factor, also known as SRF, is a transcription factor.
Serum response factor is a member of the MADS (MCM1, Agamous, Deficiens, and SRF) box superfamily of transcription factors. This protein binds to the serum response element (SRE) in the promoter region of target genes. This protein regulates the activity of many immediate early genes, for example c-fos, and thereby participates in cell cycle regulation, apoptosis, cell growth, and cell differentiation. This gene is the downstream target of many pathways; for example, the mitogen-activated protein kinase pathway (MAPK) that acts through the ternary complex factors (TCFs).
SRF is important during the development of the embryo, as it has been linked to the formation of mesoderm. In the fully developed mammal, SRF is crucial for the growth of skeletal muscle. Interaction of SRF with other proteins, such as steroid hormone receptors, may contribute to regulation of muscle growth by steroids. Interaction of SRF with other proteins such as myocardin or Elk-1 may enhance or suppress expression of genes important for growth of vascular smooth muscle.
Protein MCM10 homolog is a protein that in humans is encoded by the MCM10 gene.
The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The protein complex formed by MCM proteins is a key component of the pre-replication complex (pre-RC) and it may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein can interact with MCM2 and MCM6, as well as with the origin recognition protein ORC2. It is regulated by proteolysis and phosphorylation in a cell cycle-dependent manner. Studies of a similar protein in Xenopus suggest that the chromatin binding of this protein at the onset of DNA replication is after pre-RC assembly and before origin unwinding. Alternatively spliced transcript variants encoding distinct isoforms have been identified.
Monkeys are haplorhine ("dry-nosed") primates, a paraphyletic group generally possessing tails and consisting of approximately 260 known living species. Many monkey species are tree-dwelling (arboreal), although there are species that live primarily on the ground, such as baboons. Most species are also active during the day (diurnal). Monkeys are generally considered to be intelligent, particularly Old World monkeys.
Lemurs, lorises, and galagos are not monkeys; instead they are strepsirrhine ("wet-nosed") primates. Like monkeys, tarsiers are haplorhine primates; however, they are also not monkeys. There are two major types of monkey: New World monkeys (platyrrhines) from South and Central America and Old World monkeys (catarrhines of the superfamily Cercopithecoidea) from Africa and Asia. Hominoid apes (gibbons, orangutans, gorillas, chimpanzees, and humans), which all lack tails, are also catarrhines but are not considered monkeys. (Tailless monkeys may be called "apes", incorrectly according to modern usage; thus the tailless Barbary macaque is sometimes called the "Barbary ape".) Because old world monkeys are more closely related to hominoid apes than to new world monkeys, yet the term "monkey" excludes these closer relatives, monkeys are referred to as a paraphyletic group. Simians ("monkeys") and tarsiers emerged within haplorrhines some 60 million years ago. New world monkeys and catarrhine monkeys emerged within the simians some 35 millions years ago. Old world monkeys and Hominoidea emerged within the catarrhine monkeys some 25 millions years ago. Extinct basal simians such as Aegyptopithecus or Parapithecus [35-32 Million years ago] are also considered monkeys by primatologists.
This is a list of heraldic charges. It does not cover those charges which are geometrical patterns and resemble partitions of the field; for these, see Ordinary (heraldry).
A few simple charges are traditionally, and arbitrarily, classified among the so called subordinaries. (All other mobile charges are called common charges.)
The following types of human figures are listed in Elvin (1889):Virgin with Child, King, Bishop, Prester John, Lady Abbess, Female figure naked with flowing hair (Crest of Ellis), Figure of Justice, Figure of Hope, Man in Armour, Neptune or Triton, Mermaid, Wild Man, Roman Soldier in Armour, Moor or Blackamoor, Figure of Time, Skeleton human, Angel or Cherub, Knight on horseback (c.f. Saint George, Pahonia), Bishop, Monk (friar or hermit).