Epstein–Barr virus latent membrane protein 2
Epstein–Barr virus (EBV) latent membrane protein 2 (LMP2) are two viral proteins of the Epstein–Barr virus. LMP2A/LMP2B are transmembrane proteins that act to block tyrosine kinase signaling. LMP2A is a transmembrane protein that inhibits normal B-cell signal transduction by mimicking an activated B-cell receptor (BCR). The N-terminus domain of LMP2A is tyrosine phosphorylated and associates with Src family protein tyrosine kinases (PTKs) as well as spleen tyrosine kinase (Syk). PTKs and Syk are associated with BCR signal transduction.
LMP2 Gene Structure and Expression
Latent Membrane Protein 2 (LMP2) is a rightward transcribing gene. LMP2’s transcript originates across the fused terminal repeats in sequences at opposite ends of the genome. 16–24 hours after infection, the genome circularizes and the open reading frame is created. 1.7 kb and 2.0 kb messages are created by alternative promoter usage and differ only in the sequences of the first exon. These messages are expressed in Epstein-Barr Virus transformed lymphoblastoid cell cultures. The ratio of these messages varies widely and unpredictably suggesting little co-ordinate control of promoter activity or mRNA abundance. Residues 497 (LMP2A) and 378 (LMP2B) are encoded by these two messages. These two iso forms of LMP2 only differ in that LMP2A contains an extra 119 residue N-terminal domain encoded in exon 1. LMP2B’s first exon is non coding. Initiation of translation is presumed to occur at the first available [methionine] that is in-frame in exon two. Twelve membrane spanning segments ending with a short 28 residue COOH tail are common to both proteins in residue 379.
Le Mans Prototype
A Le Mans Prototype (LMP) is the type of sports prototype race car used in the 24 Hours of Le Mans, FIA World Endurance Championship, United SportsCar Championship, European Le Mans Series and Asian Le Mans Series. Le Mans Prototypes were created by the Automobile Club de l'Ouest (ACO). The technical requirements for an LMP include bodywork covering all mechanical elements of the car.
While not as fast as open-wheel Formula One cars, LMPs are the fastest closed-wheel racing cars used in circuit racing. Le Mans Prototypes are considered a class above production-based grand tourer cars, which compete alongside them in sports car racing.
Modern LMP designs include hybrid cars that use electric motors to assist acceleration.
Name variations
Le Mans Prototypes have used various names depending on the series in which they compete. The FIA's equivalent cars were referred to as Sports Racers (SR) or Sports Racing Prototypes (SRP). The American IMSA GT Championship termed their cars World Sports Cars' (WSC), while the short-lived United States Road Racing Championship used the classic Can-Am (CA) name for their prototypes. Since 2004, most series have switched to referring to these cars as Le Mans Prototypes. The American Le Mans Series, the successor to the IMSA GT Championship and the predecessor of the TUDOR United SportsCar Championship, officially referred to the cars simply as Prototypes (P1, P2, or PC). An LMP is commonly referred to as a Le Mans car in the media.
Epstein–Barr virus latent membrane protein 1
Epstein–Barr virus latent membrane protein 1 (LMP1) is an Epstein–Barr virus (EBV) protein that regulates its own expression and the expression of human genes. LMP1 has a molecular weight of approximately 63 kDa, and its expression induces many of the changes associated with EBV infections and activation of primary B cells. LMP1 is the best-documented oncoprotein of the EBV latent gene products, as it is expressed in most EBV-related human cancers.
The structure of LMP1 consists of a short cytoplasmic N-terminus tail, six trans-membrane domains, and a long cytoplasmic C-terminus, which contains three activating domains: CTARt, CTAR2, and CTAR3. Each CTAR domain contains an amino acid sequence that serves as a recognition site for cellular adaptors to bind and trigger a series of signal transduction pathways that can lead to a change in gene expression.
LMP-1 mediates signaling through the tumor necrosis factor-alpha/CD40 pathway.
It is often found in Reed–Sternberg cells.
Dead (disambiguation)
Dead refers to that which has experienced death.
Dead may also refer to:
Arts, entertainment, and media
Music
Artists
Albums
Songs
Television
Chemistry
See also
The Black Parade
The Black Parade is the third studio album by American rock band My Chemical Romance. Released on October 23, 2006 through Reprise Records, it was produced by Rob Cavallo, known for having produced multiple albums for Goo Goo Dolls and Green Day. It is a rock opera centering on a dying character with cancer known as "The Patient". The album tells the story of his apparent death, experiences in the afterlife, and subsequent reflections on his life.
Four singles were released from the album: "Welcome to the Black Parade", "Famous Last Words", "I Don't Love You", and "Teenagers".The Black Parade has received generally favorable reviews, and the band achieved its first Number 1 single in the UK with "Welcome to the Black Parade". The album debuted at number two on both the Billboard 200 and the UK Albums Chart and is also certified as platinum by the RIAA, as well as a Platinum certification in the UK and a Gold certification in Argentina by the CAPIF and in Chile by the IFPI Chile.The Black Parade was given the Platinum Europe Award by the International Federation of the Phonographic Industry for 1 million sales in Europe. The limited edition boxed set also earned My Chemical Romance a Grammy Award nomination. In the video game Guitar Hero II (Xbox 360 version), the song "Dead!" was added to the game's track list prior to the earlier PS2 version, and the three songs "Teenagers," "Famous Last Words" and "This Is How I Disappear" are available for download. The Black Parade has sold 1,610,000 copies in the US as of October 2010, and has sold 3,000,000 copies worldwide.
Doolittle (album)
Doolittle is the second studio album from the American alternative rock band Pixies, released in April 1989 on 4AD. The album's offbeat and dark subject material, featuring references to surrealism, Biblical violence, torture and death, contrasts with the clean production sound achieved by the newly hired producer Gil Norton. Doolittle was the Pixies' first international release, with Elektra Records acting as the album's distributor in the United States and PolyGram in Canada.
Pixies released two singles from Doolittle, "Here Comes Your Man" and "Monkey Gone to Heaven", both of which were chart successes on the US chart for Modern Rock Tracks. The album itself reached number eight on the UK Albums Chart, an unexpected success for the band. In retrospect, album tracks such as "Debaser", "Wave of Mutilation", "Monkey Gone to Heaven", "Gouge Away", and "Hey" are highly acclaimed by critics, while the album, along with debut LP Surfer Rosa, is often seen as the band's strongest work.
