Birth Through Knowledge
Birth Through Knowledge (aka BTK) was a Canadian hip-hop/rock band best known for their 1998 single "Peppyrock," the video for which was nominated for the 1998 MuchMusic Best Video Award. The band consisted of Lo-Ki (vocals), Stone Groove (vocals), DJ Spinz (turntables), Adam Carlo (bass),Sam Cino (drums,percussion) and Matt deMatteo (drums).
After signing onto the Tommyboy/Ignition label, BTK released one album "Birth Thru Knowledge" in 1998.
BTK first came to attention when their song "Corncob Pipe" was included on the sampler disc that Korn released alongside Follow the Leader. They were the first indie band to ever open the main-stage at Edgefest '97. In 1998, the band toured with the Beastie Boys and with Our Lady Peace. They appeared in the 1998 Summersault tour.
The band won the 1997 MuchMusic Best Independent Video Award for "Superchile." They were also nominated for a Juno Award in 1999 in the Best Alternative Album category, losing to Rufus Wainwright.
Footnotes
Bruton's tyrosine kinase
Bruton's tyrosine kinase (abbreviated Btk or BTK) also known as tyrosine-protein kinase BTK is an enzyme that in humans is encoded by the BTK gene. BTK is a kinase that plays a crucial role in B-cell development.
Function
BTK plays a crucial role in B cell maturation as well as mast cell activation through the high-affinity IgE receptor.
Btk contains a PH domain that binds phosphatidylinositol (3,4,5)-trisphosphate (PIP3). PIP3 binding induces Btk to phosphorylate phospholipase C, which in turn hydrolyzes PIP2, a phosphatidylinositol, into two second messengers, inositol triphosphate (IP3) and diacylglycerol (DAG), which then go on to modulate the activity of downstream proteins during B-cell signalling.
Clinical significance
Mutations in the BTK gene are implicated in the primary immunodeficiency disease X-linked agammaglobulinemia (Bruton's agammaglobulinemia). Patients with XLA have normal pre-B cell populations in their bone marrow but these cells fail to mature and enter the circulation. The Btk gene is located on the X chromosome. At least 400 mutations of the BTK gene have been identified.
Dead (disambiguation)
Dead refers to that which has experienced death.
Dead may also refer to:
Arts, entertainment, and media
Music
Artists
Albums
Songs
Television
Chemistry
See also
The Black Parade
The Black Parade is the third studio album by American rock band My Chemical Romance. Released on October 23, 2006 through Reprise Records, it was produced by Rob Cavallo, known for having produced multiple albums for Goo Goo Dolls and Green Day. It is a rock opera centering on a dying character with cancer known as "The Patient". The album tells the story of his apparent death, experiences in the afterlife, and subsequent reflections on his life.
Four singles were released from the album: "Welcome to the Black Parade", "Famous Last Words", "I Don't Love You", and "Teenagers".The Black Parade has received generally favorable reviews, and the band achieved its first Number 1 single in the UK with "Welcome to the Black Parade". The album debuted at number two on both the Billboard 200 and the UK Albums Chart and is also certified as platinum by the RIAA, as well as a Platinum certification in the UK and a Gold certification in Argentina by the CAPIF and in Chile by the IFPI Chile.The Black Parade was given the Platinum Europe Award by the International Federation of the Phonographic Industry for 1 million sales in Europe. The limited edition boxed set also earned My Chemical Romance a Grammy Award nomination. In the video game Guitar Hero II (Xbox 360 version), the song "Dead!" was added to the game's track list prior to the earlier PS2 version, and the three songs "Teenagers," "Famous Last Words" and "This Is How I Disappear" are available for download. The Black Parade has sold 1,610,000 copies in the US as of October 2010, and has sold 3,000,000 copies worldwide.
Doolittle (album)
Doolittle is the second studio album from the American alternative rock band Pixies, released in April 1989 on 4AD. The album's offbeat and dark subject material, featuring references to surrealism, Biblical violence, torture and death, contrasts with the clean production sound achieved by the newly hired producer Gil Norton. Doolittle was the Pixies' first international release, with Elektra Records acting as the album's distributor in the United States and PolyGram in Canada.
Pixies released two singles from Doolittle, "Here Comes Your Man" and "Monkey Gone to Heaven", both of which were chart successes on the US chart for Modern Rock Tracks. The album itself reached number eight on the UK Albums Chart, an unexpected success for the band. In retrospect, album tracks such as "Debaser", "Wave of Mutilation", "Monkey Gone to Heaven", "Gouge Away", and "Hey" are highly acclaimed by critics, while the album, along with debut LP Surfer Rosa, is often seen as the band's strongest work.
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