USS Shoup (DDG-86) is an Arleigh Burke-class destroyer in the United States Navy. The ship is named for General David M. Shoup (1904–1983), the 22nd Commandant of the Marine Corps.
Construction on the ship began at the Northrop Grumman Ship Systems' Ingalls Operations on 10 November 1998. Her keel was laid on 13 December 1999 and she was launched on 22 November 2000. Shoup sailed into the Gulf of Mexico for the first of her sea trials on 11 December 2001. The vessel was delivered to the Navy by Northrop Grumman on 18 February 2002 and departed Pascagoula, Mississippi on 22 April 2002. Shoup was commissioned on 22 June 2002 at Port Terminal 37 in Seattle, Washington. Her present homeport is Everett, Washington.
In July 2002, she successfully conducted the US Navy's operational evaluation of the RIM-162 Evolved Sea Sparrow Missile with two test firings.
In January 2005, she participated in Operation Unified Assistance. She was used as a filming location for the 2007 film, Transformers.