David Lat

David Benjamin Lat (born June 19, 1975) is an American lawyer, author, and legal commentator. Lat is the founder and managing editor of Above the Law, a website about law firms and the legal profession.

Before blogging, Lat attended Harvard College and Yale Law School. After law school, he worked as a law clerk for a federal appeals judge (Diarmuid F. O'Scannlain), an associate at Wachtell Lipton Rosen & Katz, and an Assistant U.S. Attorney for the appeals division in the District of New Jersey.

Lat first began blogging anonymously for the judicial gossip blog "Underneath Their Robes," until he revealed his identity in a November 2005 interview with Jeffrey Toobin of The New Yorker. Shortly thereafter, Lat launched Above the Law, a website featuring news about law firms and the legal profession and legal gossip. In December 2014, Lat published his debut novel, Supreme Ambitions.

Early life & education

David Lat is the child of Filipino doctors. He grew up in Bergenfield, New Jersey, and Saddle River, New Jersey. While living in Saddle River, his neighbors included former President Richard M. Nixon. On Halloween, he would get a Halloween card and a handshake from the former president. Lat attended Regis High School in Manhattan, New York. Lat won the Villiger Tournament for extemporaneous speaking in Philadelphia, Pennsylvania.

LAT2

Linker for activation of T-cells family member 2 is a protein that in humans is encoded by the LAT2 gene.

This gene is one of the contiguous genes at 7q11.23 commonly deleted in Williams syndrome, a multisystem developmental disorder. This gene consists of at least 14 exons, and its alternative splicing generates 3 transcript variants, all encoding the same protein.

References

Further reading

Linker of activated T cells

The Linker for Activation of T cells, also known as LAT, is a protein which in humans is encoded by the LAT gene.Alternative splicing results in multiple transcript variants encoding different isoforms.

Function

The protein encoded by this gene is phosphorylated by ZAP70/Syk protein tyrosine kinases following activation of the T-cell antigen receptor (TCR) signal transduction pathway. This transmembrane protein localizes to lipid rafts (also known as glycosphingolipid-enriched microdomains or GEMs) and acts as a docking site for SH2 domain-containing proteins. Upon phosphorylation, this protein recruits multiple adaptor proteins and downstream signaling molecules into multimolecular signaling complexes located near the site of TCR engagement.

Discovery

LAT was described in the early 1990s as a phosphoprotein of 36–38 kDa (pp. 36–38) rapidly phosphorylated on tyrosine residues following TCR ligation. Cloning of the gene revealed that the protein product is a type III (leaderless) transmembrane protein of 262 aminoacids (long form) or 233 aminoacids (short form) in humans, 242 aminoacids in mouse, and 241 aminoacids in rat.

David of Bulgaria

David (Bulgarian: Давид) (died 976) was a Bulgarian noble, brother of Emperor Samuel and eldest son of komes Nicholas. After the disastrous invasion of Rus' armies and the fall of North-eastern Bulgaria under Byzantine occupation in 971, he and his three younger brothers took the lead of the defence of the country. They executed their power together and each of them governed and defended a separate region. He ruled the southern-most parts of the realm from Prespa and Kastoria and was responsible for the defence the dangerous borders with Thessalonica and Thessaly. In 976 he participated in the major assault against the Byzantine Empire but was killed by vagrant Vlachs between Prespa and Kostur.

Family tree

Another theory

However, there's also another version about David’s origin. David gains the title "comes" during his service in the Byzantine army which recruited many Armenians from the Eastern region of the empire. The 11th-century historian Stepanos Asoghik wrote that Samuel had one brother, and they were Armenians from the district Derjan. This version is supported by the historians Nicholas Adontz, Jordan Ivanov, and Samuil's Inscription where it’s said that Samuel’s brother is David. Also, the historians Yahya and Al Makin clearly distinguish the race of Samuel and David (the Comitopouli) from the one of Moses and Aaron (the royal race):

David, Chiriquí

David (Spanish pronunciation: [daˈβið]) officially San José de David is a city and corregimiento located in the west of Panama. It is the capital of the province of Chiriquí and has an estimated population of 144,858 inhabitants as confirmed in 2013. It is a relatively affluent city with a firmly established, dominant middle class and a very low unemployment and poverty index. The Pan-American Highway is a popular route to David.

The development of the banking sector, public construction works such as the expansion of the airport and the David-Boquete highway alongside the growth of commercial activity in the city have increased its prominence as one of the fastest growing regions in the country. The city is currently the economic center of the Chiriqui province and produces more than half the gross domestic product of the province, which totals 2.1 billion. It is known for being the third-largest city in the country both in population and by GDP and for being the largest city in Western Panama.

David (Bernini)

David is a life-size marble sculpture by Gian Lorenzo Bernini. The sculpture was one of many commissions to decorate the villa of Bernini's patron Cardinal Scipione Borghese – where it still resides today, as part of the Galleria Borghese It was completed in the course of seven months from 1623 to 1624.

The subject of the work is the biblical David, about to throw the stone that will bring down Goliath, which will allow David to behead him. Compared to earlier works on the same theme (notably the David of Michelangelo), the sculpture broke new ground in its implied movement and its psychological intensity.

Background

Between 1618 and 1625 Bernini was commissioned to undertake various sculptural work for the villa of one of his patrons, Cardinal Scipione Borghese. In 1623 – only yet 24 years old – he was working on the sculpture of Apollo and Daphne, when, for unknown reasons, he abandoned this project to start work on the David. According to records of payment, Bernini had started on the sculpture by mid–1623, and his contemporary biographer, Filippo Baldinucci, states that he finished it in seven months.