Dasht-e Margo (Persian: دشت مارگو), also Dasht-e Mārgow or Dasht-e Margoh, is a desert region in the southern provinces of Helmand and Nimruz in Afghanistan. The desert is adjacent to the Dasht-e Khash and Registan Desert. It is about 150,000 km2 in area; the elevation is some 500–700 m. The desert consists mainly of sand masses and rocky-clayish plains with solonchaks, takirs, and rarely oases.
The desert's name means "Desert of Death" in Dari, with dasht meaning "desert" and margo meaning "death".