Generic top-level domain

Generic top-level domains (gTLDs) are one of the categories of top-level domains (TLDs) maintained by the Internet Assigned Numbers Authority (IANA) for use in the Domain Name System of the Internet. A top-level domain is the last label of every fully qualified domain name. They are called generic for historic reasons; initially, they were contrasted with country-specific TLDs in RFC 920.

The core group of generic top-level domains consists of the com, info, net, and org domains. In addition, the domains biz, name, and pro are also considered generic; however, these are designated as restricted, because registrations within them require proof of eligibility within the guidelines set for each.

Historically, the group of generic top-level domains included domains, created in the early development of the domain name system, that are now sponsored by designated agencies or organizations and are restricted to specific types of registrants. Thus, domains edu, gov, int, and mil are now considered sponsored top-level domains, much like the themed top-level domains (e.g., jobs). The entire group of domains that do not have a geographic or country designation (see country-code top-level domain) is still often referred to by the term generic TLDs.

Shut Out (album)

Shut Out is the debut album by American actor, singer and songwriter Paul Jabara.

The album which was released on the Casablanca Records label in 1977 includes the singles "Shut Out" (a duet with Donna Summer), "Dance" and "Slow Dancing". The original LP was pressed on red vinyl.

Shut Out has yet to be re-released on CD.

Track listing

Dance (Disco Heat)

"Dance (Disco Heat)" is the title of a 1978 single by American disco singer Sylvester James, who performed using just his first name, Sylvester. The song became Sylvester's first Top 40 hit in the US, where it peaked at #19 on the Billboard Hot 100 chart in the fall of 1978; it also reached #29 on the UK Singles Chart. The song appears on his 1978 album, Step II.

A 12" single was released in 1978, with "Dance (Disco Heat)" as the A-side and "You Make Me Feel (Mighty Real)" as the B-side, and these two extended dance mixes proved to be very popular in the dance clubs at the time. The two songs held down the top spot on the Billboard Dance/Disco chart for six weeks in August and September of that year and helped to establish Sylvester's career as a noted disco and dance music performer, both in the U.S. and abroad.

References

External links

Argonaute

The Argonaute protein family plays a central role in RNA silencing processes, as essential catalytic components of the RNA-induced silencing complex (RISC). RISC complex is responsible for the gene silencing phenomenon known as RNA interference (RNAi). Argonaute proteins bind different classes of small non-coding RNAs, including microRNAs (miRNAs), small interfering RNAs (siRNAs) and Piwi-interacting RNAs (piRNAs). Small RNAs guide Argonaute proteins to their specific targets through sequence complementarity (base pairing), which then leads to mRNA cleavage or translation inhibition.

Discovery

The RNA interference (RNAi) was first reported in 1995 by Guo and Kemphues, and similar pathways collectively referred to as RNA silencing were discovered in plants and fungi. The beginning of people’s understanding of the mechanism of RNA silencing began only in 1998 with the experiments of Fire and colleagues demonstrating that double-stranded RNA triggered RNAi. RNA silencing pathways process long RNAs into small RNAs that direct the repression of transcription or translation of nucleic acid targets with sequence corresponding to the small RNAs. These single-stranded RNAs, referred to as guide strands, are incorporated into RNA silencing effectors complexes such as the RNA-induced silencing complex (RISC). These RNA silencing effector complexes contain Argonaute family proteins.