| Dachshund homolog 2 (Drosophila) | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||||
| Symbols | DACH2; [] | ||||||||||||
| External IDs | OMIM: 300608 HomoloGene: 33472 GeneCards: DACH2 Gene | ||||||||||||
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| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 117154 | 93837 | |||||||||||
| Ensembl | ENSG00000126733 | ENSMUSG00000025592 | |||||||||||
| UniProt | Q96NX9 | Q925Q8 | |||||||||||
| RefSeq (mRNA) | NM_001139514.1 | NM_001142570.1 | |||||||||||
| RefSeq (protein) | NP_001132986.1 | NP_001136042.1 | |||||||||||
| Location (UCSC) | Chr X: 85.4 – 86.09 Mb |
Chr X: 110.41 – 110.95 Mb |
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| PubMed search | [1] | [2] | |||||||||||
Dachshund homolog 2 is a protein that in humans that is encoded by the DACH2 gene.[1]
Function [link]
This gene is one of two genes which encode a protein similar to the Drosophila protein dachshund, a transcription factor involved in cell fate determination in the eye, limb and genital disc of the fly. The encoded protein contains two characteristic dachshund domains: an N-terminal domain responsible for DNA binding and a C-terminal domain responsible for protein-protein interactions. This gene is located on the X chromosome and is subject to inactivation by DNA methylation. The encoded protein may be involved in regulation of organogenesis and myogenesis, and may play a role in premature ovarian failure.
References [link]
- ^ Multiple transcript variants encoding different isoforms have been found for this gene. "Entrez Gene: Dachshund homolog 2 (Drosophila)". https://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=retrieve&list_uids=117154. Retrieved 2012-04-15T07:31:30.142193-08:00.
Further Reading [link]
- Bione, S.; Rizzolio, F.; Sala, C.; Ricotti, R.; Goegan, M.; Manzini, M. C.; Battaglia, R.; Marozzi, A. et al. (2004). "Mutation analysis of two candidate genes for premature ovarian failure, DACH2 and POF1B". Human Reproduction 19 (12): 2759–2766. DOI:10.1093/humrep/deh502. PMID 15459172.
- Poulin, F.; Nobrega, M. A.; Plajzer-Frick, I.; Holt, A.; Afzal, V.; Rubin, E. M.; Pennacchio, L. A. (2005). "In vivo characterization of a vertebrate ultraconserved enhancer". Genomics 85 (6): 774–781. DOI:10.1016/j.ygeno.2005.03.003. PMID 15885503.
- Davis, R. J.; Shen, W.; Sandler, Y. I.; Heanue, T. A.; Mardon, G. (2001). "Characterization of mouse Dach2, a homologue of Drosophila dachshund". Mechanisms of development 102 (1–2): 169–179. PMID 11287190.
- Aikawa, Y.; Nguyen, L. A.; Isono, K.; Takakura, N.; Tagata, Y.; Schmitz, M. L.; Koseki, H.; Kitabayashi, I. (2006). "Roles of HIPK1 and HIPK2 in AML1- and p300-dependent transcription, hematopoiesis and blood vessel formation". The EMBO Journal 25 (17): 3955–3965. DOI:10.1038/sj.emboj.7601273. PMC 1560355. PMID 16917507. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1560355.
- Prueitt, R. L.; Chen, H.; Barnes, R. I.; Zinn, A. R. (2002). "Most X;autosome translocations associated with premature ovarian failure do not interrupt X-linked genes". Cytogenetic and genome research 97 (1–2): 32–38. PMID 12438735.
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https://wn.com/DACH2
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I might let you tease me
I might let you squeeze me
I might even let you kiss me
But you can not take my virginity
I might let you touch me
I might let you hold me
I might even let you kiss me
But you can not take my virginity
I might let you tease me
I might let you squeeze me
I might even let you kiss me
But you can not take my virginity
I might let you touch me
I might let you hold me
I might even let you kiss me
But you can not take my virginity
I might let you tease me
I might let you squeeze me
I might even let you kiss me