DYRK1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A is an enzyme that in humans is encoded by the DYRK1A gene. Alternative splicing of this gene generates several transcript variants differing from each other either in the 5' UTR or in the 3' coding region. These variants encode at least five different isoforms.
Function
DYRK1A is a member of the dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) family. This member contains a nuclear targeting signal sequence, a protein kinase domain, a leucine zipper motif, and a highly conservative 13-consecutive-histidine repeat. It catalyzes its autophosphorylation on serine/threonine and tyrosine residues. It may play a significant role in a signaling pathway regulating cell proliferation and may be involved in brain development. This gene is a homolog of Drosophila mnb (minibrain) gene and rat Dyrk gene.
Dyrk1a has also been shown to modulate plasma homocysteine level in a mouse model of overexpression.
Clinical significance
Podcasts:
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by Tim McGraw
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by Cake
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by Kelis
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by Happy Rhodes
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by Public Image Ltd
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by Rotten Sound
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by Dark Lotus
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by Trews
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by Parokya Ni Edgar
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by Ohgr
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by Corey Smith
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by Showoff
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by J-Kwon
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by Interlace
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by Audience Of One
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by Audience Of One
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by Audience Of One
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by Chris Moyles
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by Cale Hawkins
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by Lia
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by Grieves
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by Go-betweens
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by Wwf
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by Half Moon Run
Truck Yeah
by: Tim McGrawGot Lil' Wayne pumpin' on my iPod
Pumpin' on the subs in the back of my crew cab
Redneck rockin' like a rockstar
Sling a lil' mud off the back, we can do that
Friday night football, Saturday Last Call, Sunday Hallelujah
If you like it up loud and you're hillbilly proud
Then you know what I'm talking about
Let me hear you say, Truck Yeah
Wanna get it jacked up yeah
Let's crank it on up yeah
With a little bit of luck I can find me a girl with a Truck Yeah
We can love it on up yeah
'Til the sun comes up yeah
And if you think this life I love is a little too country
Truck Yeah
Our party in the club is a honky tonk downtown
Yeah that's where I like to hang out
Chillin' in the back room
Hangin' with my whole crew
Sippin' on a cold brew, hey now!
Got a mixed up playlist, DJ play this
Wanna hear a country song
If you like it up loud and you're hillbilly proud
Throw your hands up now, let me hear you shout
Truck Yeah
Wanna get it jacked up yeah
Let's crank it on up yeah
With a little bit of luck I can find me a girl with a Truck Yeah
We can love it on up yeah
'Til the sun comes up yeah
And if you think this life I love is a little too country
Truck Yeah
Rap or country, city farm
It don't matter who you are
Got a little fight, got a little love
Got a little redneck in your blood
Are you one of us?
Truck Yeah
Wanna get it jacked up yeah
Let's crank it on up yeah
With a little bit of luck I can find me a girl with a Truck Yeah
We can love it on up yeah
'Til the sun comes up yeah
And if you think this life I love is a little too country
You're right on the money