Dopamine receptor D5

Dopamine receptor D5, also known as D1BR, is a protein that in humans is encoded by the DRD5 gene. It belongs to the D1-like receptor family along with the D₁ receptor subtype.

Function

D₅ receptor is a subtype of the dopamine receptor that has a 10-fold higher affinity for dopamine than the D₁ subtype. The D₅ subtype is a G-protein coupled receptor, which promotes synthesis of cAMP by adenylyl cyclase via activation of Gα_s/olf family of G proteins. Both D₅ and D₁ subtypes activate adenylyl cyclase. D₁ receptors were shown to stimulate monophasic dose-dependent accumulation of cAMP in response to dopamine, and the D₅ receptors were able to stimulate biphasic accumulation of cAMP under the same conditions, suggesting that D₅ receptors may use a different system of secondary messengers than D₁ receptors.

Activation of D₅ receptors is shown to promote expression of brain-derived neurotrophic factor and increase phosphorylation of protein kinase B in rat and mice prefrontal cortex neurons.