DPP

DPP may stand for:

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Politics

Medicine and science

Democratic Progressive Party (Singapore)

The Democratic Progressive Party (abbrev: DPP; Chinese: 民主进步党; Malay: Parti Demokratik Progresif) is a political party in Singapore.

History and political development

The history of the party dates to 16 March 1973 when the United Front was formed by a splinter group from the Workers' Party led by Seow Khee Leng (former Assistant Secretary-General of WP, 1971–1972). The United Front contested three consecutive elections (1976 general election, 1979 by-election and 1980 general election) before being renamed the Singapore United Front on 5 March 1982, and contested again in the 1984 general election. SUF chief Seow Khee Leng was then sued by Lee Kuan Yew and the ruling PAP government over defamatory remarks made at two rally speeches that Lee and his cabinet were guilty of corruption.

In January 1988, the party merged with Workers' Party to contest the 1988 general election and the Singapore United Front became defunct (though the party remained an officially registered organisation).

Dipeptidyl peptidase-4

Dipeptidyl peptidase-4 (DPP4), also known as adenosine deaminase complexing protein 2 or CD26 (cluster of differentiation 26) is a protein that, in humans, is encoded by the DPP4 gene. DPP4 is related to attractin, FAP, DPP8 and DPP9.

Function

The protein encoded by the DPP4 gene is an antigenic enzyme expressed on the surface of most cell types and is associated with immune regulation, signal transduction and apoptosis. It is an intrinsic membrane glycoprotein and a serine exopeptidase that cleaves X-proline dipeptides from the N-terminus of polypeptides.

It is a rather indiscriminate enzyme for which a diverse range of substrates are known. The substrates of CD26/DPPIV are proline(or alanine)-containing peptides and include growth factors, chemokines, neuropeptides, and vasoactive peptides. DPP4 plays a major role in glucose metabolism. It is responsible for the degradation of incretins such as GLP-1. Furthermore, it appears to work as a suppressor in the development of cancer and tumours.